诱导多能干细胞瘤变的研究进展  

Research Progress in Induced Pluripotent Stem Cell Neoplasia

作　　者：秦勇[1] 孙君[2] 谢模芬 

机构地区：[1]重庆医科大学附属儿童医院放射科,重庆 [2]重庆大学附属中心医院(重庆市急救医疗中心,重庆市第四人民医院)放射科,重庆 [3]重庆市中医院骨科,重庆

出　　处：《临床医学进展》2024年第3期105-110,共6页Advances in Clinical Medicine

摘　　要：诱导多能干细胞(IPSC)是体细胞重编程后得到的与胚胎干细胞相似的具有自我更新和多向分化潜能的细胞,这一发现成功避开了胚胎干细胞的伦理问题。自IPSC问世,这项技术就迅速应用于疾病建模、药物开发、再生医学和基因调控,尤其是再生医学自体移植研究领域。但是,IPSC移植后瘤变成为IPSC用于再生医学的一大阻碍,因此IPSC的瘤变成为当前IPSC研究的热点问题。本文就IPSC与肿瘤细胞的关系、IPSC移植后成瘤机制、降低IPSC移植后瘤变率以及IPSC移植后体内监测技术等几个方面进行简要综述。IPSC is obtained through somatic cell reprogramming, which has similar self-renewal and mul-ti-directional differentiation potential to embryonic stem cells (ESCs) and avoids the ethical issues of ESCs successfully. Since IPSC was invented, it has been rapidly applied in disease modeling, drug development, regenerative medicine, and gene regulation, especially in the field of regenerative medicine research. However, IPSC post-transplantation tumors have become a major obstacle to the use of IPSC for regenerative medicine, and thus tumors in IPSC have become a hot issue in current IPSC research. This article provides a brief review on the relationship between IPSC and tumor cells, the malignant transformation of IPSC after transplantation and how to reduce it, and in vivo monitoring techniques of IPSC.

关 键 词：诱导多能干细胞 生物安全 体内示踪 磁共振成像 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]