GLP-1RA促进脂肪组织米色化  

GLP-1RA Promotes Beige Differentiation in Adipose Tissue

作　　者：刘臻 

机构地区：[1]山东第一医科大学附属中心医院代谢疾病中心,山东 济南

出　　处：《临床医学进展》2024年第3期947-953,共7页Advances in Clinical Medicine

摘　　要：肥胖症是一种与脂肪组织功能失调相关的代谢病。在肥胖症中观察到棕色脂肪组织数量减少,棕色脂肪组织专门从事非颤抖产热能量消耗。在过去的研究中发现一种称为“米色化”的分化机制,可以产生棕色脂肪细胞,进而增强产热作用抵抗肥胖。除食欲抑制剂和营养吸收抑制剂外,棕色脂肪组织激活剂也是治疗肥胖的一种选择。最近研究表明,肠道激素胰高血糖素样肽-1 (GLP-1)除调节外周葡萄糖外,在肥胖治疗中抑制食欲和能量代谢也起到一定作用。GLP-1受体激动剂也被证明作用于神经系统、胃肠道、脂肪组织调节能量稳态。本文综合论述了过去研究中GLP-1受体激动剂促进脂肪组织米色化进而治疗肥胖症的生理现象以及相关机制。Obesity is a metabolic disorder associated with dysfunction of adipose tissue. In obesity, a decrease in the number of brown adipose tissue is observed, which specializes in non-trembling thermogenic energy consumption. In previous studies, a differentiation mechanism called “beige differentiation” has been found to produce brown adipocytes, thereby enhancing thermogenesis and resisting obe-sity. In addition to appetite inhibitors and nutrient absorption inhibitors, brown adipose tissue ac-tivators are also an option for treating obesity. Recent studies have shown that the gut hormone glucagon like peptide-1 (GLP-1) not only regulates peripheral glucose, but also plays a certain role in inhibiting appetite and energy metabolism in obesity treatment. GLP-1 receptor agonists have also been shown to act on the nervous system, gastrointestinal tract, and adipose tissue to regulate energy homeostasis. This article comprehensively discusses the physiological phenomena and re-lated mechanisms of GLP-1 receptor agonists promoting beige differentiation in adipose tissue and treating obesity in previous studies.

关 键 词：肥胖 GLP-1RA 棕色脂肪组织 米色化 

分 类 号：R58[医药卫生—内分泌]