他汀类药物在抗肿瘤药物引起的心脏毒性中的保护作用  

Protective Effect of Statins on Cardiotoxicity Induced by Antitumor Drugs

作　　者：田鹏 孟婷婷 张钰 刘安邦 郑燕[2,4] 苏国海 

机构地区：[1]山东大学齐鲁医学院,山东 济南 [2]济南市中心医院心内科,山东 济南 [3]山东第一医科大学附属中心医院,山东 济南 [4]济南市中心医院专科转化中心,山东 济南

出　　处：《临床医学进展》2024年第3期1317-1322,共6页Advances in Clinical Medicine

摘　　要：他汀类药物属于羟甲基戊二酰辅酶A (HMG-CoA)还原酶抑制剂,可抑制胆固醇生物合成,抗动脉粥样硬化,已经广泛用于冠状动脉粥样硬化性心脏病的治疗,近年来有研究发现他汀类药物在抗肿瘤药物所致心脏毒性中有保护作用。本文对相关报道进行综述,以期对肿瘤患者心血管损伤的预防、治疗提供思路。Statins are hydroxymethylglutaryl-Coenzyme A (HMG-CoA) reductase inhibitors, which can inhibit cholesterol biosynthesis and anti-atherosclerosis, and have been widely used in the treatment of coronary atherosclerotic heart disease. In recent years, studies have found that statins have a pro-tective effect on cardiotoxicity caused by anti-tumor drugs. In this paper, related reports are re-viewed in order to provide ideas for the prevention and treatment of cardiovascular injury in cancer patients.

关 键 词：心脏毒性 他汀类药物 抗肿瘤药物 冠状动脉粥样硬化性心脏病 心血管损伤 还原酶抑制剂 羟甲基戊二酰辅酶A 抗动脉粥样硬化 

分 类 号：R54[医药卫生—心血管疾病]