靶向衰老细胞在骨关节炎治疗中的研究进展  

Research Progress in Targeting Senescent Cells in the Treatment of Osteoarthritis

作　　者：王鹏[1] 满振涛 李伟[1] 

机构地区：[1]山东大学,山东 济南 [2]山东第一医科大学附属省立医院骨关节科,山东 济南

出　　处：《临床医学进展》2024年第4期519-525,共7页Advances in Clinical Medicine

摘　　要：细胞衰老是指一种永久性的细胞周期终止状态,能够影响机体的发育及动态平衡。它和许多与衰老相关的疾病有关,比如骨关节炎。目前关于衰老细胞与骨关节炎之间的研究主要集中在寻找能够清除衰老细胞或选择性阻断衰老相关分泌表型(SASP)以阻止疾病进展的药物疗法。随着对细胞衰老和SASP新机制以及其靶点的探索,潜在的治疗方法将不断增加。本文将探讨细胞衰老的相关机制,并讨论针对每个靶点的治疗方案及其优势。Cellular senescence is a state of permanent cell cycle termination that can affect the development and dynamic homeostasis of the organism. It is associated with many diseases related to aging, such as osteoarthritis. Current research on the link between senescent cells and osteoarthritis is focused on finding drug therapies that can remove senescent cells or selectively block senescence- associated secretory phenotypes (SASPs) to halt disease progression. As new mechanisms of cellular senescence and SASP, as well as their targets, are explored, the potential therapeutic approaches will continue to grow. This article will explore the mechanisms involved in cellular senescence and discuss therapeutic options for each target and their advantages.

关 键 词：骨关节炎 细胞衰老 衰老相关分泌表型 软骨细胞 综述 

分 类 号：R68[医药卫生—骨科学]