脓毒症急性肾损伤的生物标记物研究进展  

Research Progress on Biomarkers of Sepsis-Induced Acute Kidney Injury

作　　者：邓翔宇 薛建江 

机构地区：[1]重庆医科大学第四临床学院,重庆

出　　处：《临床医学进展》2024年第5期201-207,共7页Advances in Clinical Medicine

摘　　要：脓毒症(sepsis)是由感染引起的全身炎症反应综合征,可导致危及生命的器官功能障碍。脓毒症急性肾损伤(SA-AKI)是危重患者的常见并发症,发病率和死亡率居高不下,早期诊断SA-AKI对临床医师指导治疗和避免肾脏进一步损害至关重要。但至今SA-AKI的早期诊断仍存在许多不足,如何早发现早诊治一直是学术界研究的热点。近年来,随着对SA-AKI病理生理机制的深入研究,一些新兴的潜在生物标记物被发现。本篇综述旨在结合近年来学术界研究新进展对SA-AKI的生物标记物进行总结归纳。Sepsis is a systemic inflammatory response syndrome caused by infection, which can lead to life-threatening organ dysfunction. Sepsis-induced acute kidney injury (SA-AKI) is a common complication in critically ill patients with high morbidity and mortality. Early diagnosis of SA-AKI is essential for clinicians to guide treatment and avoid further kidney damage. However, there are still many deficiencies in the early diagnosis of SA-AKI. How to detect and diagnose SA-AKI as early as possible has always been a hot topic in academic research. In recent years, with the in-depth study of the pathophysiological mechanism of SA-AKI, some emerging potential biomarkers have been discovered. This review aims to summarize the biomarkers of SA-AKI based on the new progress of academic research in recent years.

关 键 词：脓毒症急性肾损伤 生物标志物 早期诊断 

分 类 号：R47[医药卫生—护理学]