基于肠道菌群探讨中医药防治高血压合并2型糖尿病  

To Explore the Prevention and Treatment of Hypertension Complicated with Type 2 Diabetes Mellitus by Traditional Chinese Medicine Based on Intestinal Flora

作　　者：黄琪娜 李杨[2] 郑绍琼 

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第一医院中医经典病房,黑龙江 哈尔滨

出　　处：《临床医学进展》2024年第5期291-298,共8页Advances in Clinical Medicine

摘　　要：高血压是以体循环动脉压升高为主要临床表现的心血管综合征,是临床上常见的慢性疾病。高血压和2型糖尿病是两种互相影响的代谢性疾病。高血压是糖尿病的危险因素,并且通常先于糖尿病的发展,二者共存会对多器官造成严重损害,而发生心血管疾病的风险更是普通人群的4~8倍。肠道菌群在新生儿出生后便存在于肠道中,主要包括厚壁菌门和拟杆菌门。肠道微生物参与人体代谢时会产生氧化三甲胺、脂多糖、短链脂肪酸等物质,这些代谢产物可在肠外发挥一系列作用。高血压及糖尿病的发生发展与肠道微生物密切相关,肠道菌群已成为新的治疗靶点。本文基于肠道菌群探讨中医药对高血压合并2型糖尿病的防治,通过探究并阐明肠道菌群与高血压合并2型糖尿病的相关性,为中医药防治该合并症提供新的思路。Hypertension is a cardiovascular syndrome with elevated systemic arterial pressure as the main clinical manifestation. It is a common chronic disease in clinic. Hypertension and type 2 diabetes are two metabolic diseases that affect each other. Hypertension is a risk factor for diabetes, and usually precedes the development of diabetes. The coexistence of the two can cause serious damage to multiple organs, and the risk of cardiovascular disease is 4 to 8 times higher than that of the general population. Intestinal flora exists in the intestine after birth, mainly including Firmicutes and Bacteroidetes. Intestinal microorganisms produce trimethylamine oxide, lipopolysaccharide, short-chain fatty acids and other substances when they participate in human metabolism. These metabolites can play a series of roles outside the intestine. The occurrence and development of hypertension and diabetes are closely related to intestinal microorganisms, and intestinal flora has become a new therapeutic target. Based on the intestinal flora, this paper discusses the prevention and treatment of hypertension combined with type 2 diabetes mellitus by traditional Chinese medicine. By exploring and clarifying the correlation between intestinal flora and hypertension combined with type 2 diabetes mellitus, it provides new ideas for the prevention and treatment of this complication by traditional Chinese medicine.

关 键 词：肠道菌群 高血压 2型糖尿病 

分 类 号：R54[医药卫生—心血管疾病]