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出 处:《临床医学进展》2024年第6期334-343,共10页Advances in Clinical Medicine
摘 要:目的:通过检测全孕期健康女性血清抗心磷脂(aCL)及抗β2糖蛋白1抗体(aβ2GPI)水平,建立郑州市健康孕期抗体的参考区间,分析孕期抗体变化的特点及临床意义。方法:纳入2023.5~2023.10于郑大二附院建档围保的134名健康孕期女性检测aCL和aβ2GPI-IgA/IgM/IgG血清水平,使用非参数法计算各百分位值,同期纳入78例孕前检测抗磷脂抗体阳性的孕妇,收集其孕后抗体水平及治疗用药和妊娠结局。结果:1) 正常妊娠妇女剔除离群值后,aCL和aβ2GPI-IgA/IgM/IgG的P99值分别为:4.78 RU/mL、29.18 RU/mL、3.33 RU/mL、4.88 RU/mL、11.44 RU/mL、β2GPI-IgM水平显著降低(P β2GPI-IgM水平显著降低,抗体阳性者孕后其水平显著降低,孕前APLs升高2.725倍与不良妊娠结局相关。Objective: By detecting serum levels of anticardiolipin (aCL) and anti-β-2-glycoprotein I antibody (aβ2GPI) in healthy women throughout pregnancy, establish a reference interval for healthy pregnancy antibodies in Zhengzhou city, and analyze the characteristics and clinical significance of changes in pregnancy antibodies. Method: Serum levels of aCL and aβ2GPI-IgA/IgM/IgG were tested in 134 healthy pregnant women who were included in the perioperative period of the Second Affiliated Hospital of Zhengzhou University from March 3, 2023 to October 2023. Non parametric methods were used to calculate the percentile values. During the same period, 78 pregnant women who tested positive for antiphospholipid antibodies before pregnancy were included, and their post pregnancy antibody levels, treatment medication, and pregnancy outcomes were collected. Result: 1) After excluding outliers in normal pregnant women, The P99 of aCL and aβ2GPI-IgA were 4.78 RU/mL, 29.18 RU/mL, 3.33 RU/mL, 4.88 RU/mL, 11.44 RU/mL, and β2GPI-IgM significantly decreased (P β2GPI-IgM in healthy pregnant women were significantly reduced, and those who were antibody positive had a significant decrease in their levels after pregnancy. An increase of 2.725 times in pre pregnancy APLs was associated with adverse pregnancy outcomes.
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