生长激素缺乏症与生长激素激发试验  

Growth Hormone Deficiency and Growth Hormone Stimulation Test

作　　者：孙胜彬 罗雁红[1,2,3,4,5] 

机构地区：[1]重庆医科大学附属儿童医院内分泌科,重庆 [2]儿童发育疾病研究教育部重点实验室,重庆 [3]国家儿童健康与疾病临床医学研究中心,重庆 [4]儿童发育重大疾病国家国际科技合作基地,重庆 [5]儿童代谢与炎症性疾病重庆市重点实验室,重庆

出　　处：《临床医学进展》2024年第6期1587-1592,共6页Advances in Clinical Medicine

摘　　要：生长激素缺乏症可导致儿童身材矮小,是小儿矮小症重要病因之一,现已受到越来越多儿科内分泌医生的关注,及时应用重组生长激素替代治疗可以有效改善患儿终身高。生长激素激发试验是诊断生长激素缺乏症的重要方法,更多认识生长激素激发试验才能更好地在临床中诊断生长激素缺乏症。生长激素激发试验已有很多临床研究,不同激发试验生长激素峰值存在不同,体质指数与生长激素峰值呈负相关。生长激素激发试验判读阈值现国内外无统一标准,部分国家已经下调诊断阈值,我国现仍沿用10 ug/L的诊断阈值。Growth hormone deficiency can cause childhood short stature and is one of the major causes of pediatric short stature. It has increasingly attracted the attention of pediatric endocrinologists. Timely application of recombinant human growth hormone replacement therapy can effectively improve the final height of affected children. The growth hormone stimulation test is an important method for diagnosing growth hormone deficiency, and a deeper understanding of this test can better facilitate the clinical diagnosis of growth hormone deficiency. There have been many clinical studies on the growth hormone stimulation test, and different tests have shown varying peak growth hormone levels. Body mass index is negatively correlated with peak growth hormone levels. Currently, there is no unified standard for interpreting the threshold values of the growth hormone stimulation test, and some countries have already lowered the diagnostic threshold. However, in China, the diagnostic threshold of 10 ug/L is still being used.

关 键 词：生长激素缺乏症 生长激素激发试验 生长激素峰值 

分 类 号：R72[医药卫生—儿科]