心成纤维细胞在心脏衰老中的研究进展  

Research Progress of Cardiac Fibroblasts in Cardiac Aging

作　　者：尤浩鹏 孔令阁[1] 

机构地区：[1]内蒙古民族大学第二临床医学院,内蒙古 通辽

出　　处：《临床医学进展》2024年第7期172-178,共7页Advances in Clinical Medicine

摘　　要：心血管疾病是全球发病率和死亡率的主要原因,心脏衰老的特征是细胞和分子变化的集合体,年龄驱动的心脏再生能力下降加剧了这种变化。尽管心脏衰老的表型得到了很好的表征,但潜在的分子机制却很少被探索。最近的研究表明,盘状蛋白结构域受体2 (DDR2)是一种主要位于心脏成纤维细胞中的胶原激活受体酪氨酸激酶,在心脏成纤维细胞功能和心血管纤维化中具有专性作用。对衰老心脏中心血管衰老和成纤维细胞功能失调的分子基础的敏锐研究将为缓解快速增长的老年人口心血管疾病的有效策略铺平道路。Cardiovascular disease is a leading cause of morbidity and mortality worldwide, and cardiac aging is characterized by a conglomeration of cellular and molecular changes exacerbated by age-driven declines in the heart’s regenerative capacity. Although the phenotype of cardiac aging is well characterized, the underlying molecular mechanisms have been little explored. Recent studies have shown that disc protein domain receptor 2 (DDR2), a collagen-activated receptor tyrosine kinase located primarily in cardiac fibroblasts, has an obligate role in cardiac fibroblast function and cardiovascular fibrosis. Acute research into the molecular basis of vascular senescence and fibroblast dysfunction in aging hearts will pave the way for effective strategies to mitigate cardiovascular disease in the rapidly growing elderly population.

关 键 词：DDR2 老化 心脏成纤维细胞 心脏纤维化 心脏细胞 胶原蛋白 衰老 

分 类 号：R54[医药卫生—心血管疾病]