BMP9对动脉性肺动脉高压肺血管内皮细胞影响的研究进展  

Research Progress on the Effect of BMP9 on Pulmonary Vascular Endothelial Cells in Pulmonary Arterial Hypertension

作　　者：高婷[1] 王丽红 

机构地区：[1]青岛大学附属烟台毓璜顶医院超声科,山东 烟台

出　　处：《临床医学进展》2024年第8期1195-1200,共6页Advances in Clinical Medicine

摘　　要：动脉性肺动脉高压(Pulmonary Arterial Hypertension, PAH),即第1大类肺动脉高压,是一种以高发病率和死亡率为特点的血管疾病,其主要表现是肺血管重塑和肺血管阻力增加,最终导致右心室衰竭甚至死亡。骨形态发生蛋白9 (Bone Morphogenetic Protein 9, BMP9)属于转化生长因子β (Transforming Growth Factor-β, TGF-β)家族,主要由肝脏星状细胞产生,随血液循环到肺血管内皮细胞上与受体结合,在PAH中发挥相应的生物学效应,但是部分研究结果是相互矛盾的。本文对PAH中BMP9的信号通路及BMP9对肺血管内皮细胞作用的研究和进展进行综述。Arterial pulmonary hypertension (PAH), also known as the group 1 pulmonary hypertension, is a vascular disease characterized by high morbidity and mortality, and its main manifestations are pulmonary vascular remodeling and increased pulmonary vascular resistance, which eventually leads to right ventricular failure and even death. Bone Morphogenetic Protein 9 (BMP9) belongs to the Transforming Growth Factor-β (TGF-β) family, which is mainly produced by hepatic stellate cells, which circulates to pulmonary vascular endothelial cells with blood and bind to their receptors to exert corresponding biological effects in PAH, but some research results are contradictory. This article briefly reviews the BMP9 signaling pathway in PAH and the research and progress of BMP9 on pulmonary vascular endothelial cells.

关 键 词：动脉性肺动脉高压 BMP9 BMPRII 肺血管内皮细胞 肺血管重塑 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]