血清CCN5与房颤患者左房低电压面积的相关性研究  

The Study of Correlation between Serum CCN5 and Left Atrial Low-Voltage Area in Patients with Atrial Fibrillation

作　　者：李红叶 王春筱 任蒙蒙 龚磊[2] 仲琳[2] 

机构地区：[1]青岛大学医学部,山东 青岛 [2]烟台毓璜顶医院心血管内科,山东 烟台

出　　处：《临床医学进展》2024年第9期219-228,共10页Advances in Clinical Medicine

摘　　要：目的:探讨房颤患者血清CCN5水平是否可以预测左房低电压面积(LVZ)的大小。方法:选取2023年6月到2024年1月于烟台毓璜顶医院就诊的窦性心律患者(对照组) 79例以及首次接受心脏射频消融术的房颤患者(房颤组)114例。收集一般资料、生化、心电图、心脏超声等临床资料。按术中行基质电压标测所得的LVZ是否大于6%将患者分为A组(LVZ Objective: To explore whether the serum CCN5 levels associated with atrial fibrosis can predict LVZ in patients with atrial fibrillation. Methods: In this study, 79 patients with sinus rhythm (control group) and 114 patients with atrial fibrillation (atrial fibrillation group) who received radiofrequency cardiac ablation for the first time in Yantai Yuhuangding Hospital between June 2023 and January 2024 were enrolled. General data, biochemistry, electrocardiogram, cardiac ultrasound and other clinical data were collected. Left atrial stroma voltage mapping was performed in patients with atrial fibrillation and LVZ area ratio was calculated. Patients were divided into group A (LVZ < 6%) and group B (LVZ ≥ 6%) according to whether LVZ was greater than 6%. The expression level of CCN5 in peripheral blood was measured by enzyme-linked immunosorbent assay. T test was used to compare the CCN5 expression level between the control group and the atrial fibrillation group. Pearson or Spearman correlation analysis was used to explore the correlation between CCN5 and clinical data. Binary Logistic regression analysis was used to determine the risk factors affecting the LVZ, and receiver operating characteristic (ROC) analysis was down to determine the cut-off value of CCN5 to predict LVZ. Results: The level of CCN5 in patients with atrial fibrillation was lower than in control group (32.43 ± 6.15 vs. 25.46 ± 4.97, P < 0.001). For atrial fibrillation patients with LVZ < 6%, blood CCN5 expression levels were lower in patients with LVZ ≥ 6% (30.10 ± 6.75 vs. 24.75 ± 3.49, P < 0.001). In patients wi

关 键 词：心房颤动 心脏射频消融术 CCN5 左房低电压区 生物标志物 

分 类 号：R54[医药卫生—心血管疾病]