AST/ALT比值与尿白蛋白/肌酐比值(ACR)相关性研究:从生物标志物到临床应用  

Correlation Study of AST/ALT Ratio and Urinary Albumin/Creatinine Ratio (ACR): From Biomarkers to Clinical Applications

作　　者：张智超 胡豪飞 何永成 

机构地区：[1]川北医学院附属医院肾内科,四川 南充 [2]深圳市第二人民医院肾内科,广州 深圳

出　　处：《临床医学进展》2024年第10期49-55,共7页Advances in Clinical Medicine

摘　　要：天门冬氨酸氨基转移酶(AST)与丙氨酸氨基转移酶(ALT)比值(AAR),传统上用于肝脏功能评估,近年来研究发现它与肝外疾病,如心血管疾病、代谢综合征和肾脏功能等存在关联。尿白蛋白肌酐比(ACR)作为肾脏敏感指标,在预测心血管风险、脑卒中、糖尿病和全因死亡率方面具有重要意义。本文旨在探讨AST/ALT比值与ACR相关潜在机制的关联性,以利用这两个指标全面评估人体健康,并通过它们的关系,利用肝损伤指标预测肾脏状况,从而对肾病患者实施早期临床管理。The ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT), traditionally known as the AST/ALT ratio (AAR), has been used for the assessment of liver function. Recent studies have identified its association with extrahepatic diseases, such as cardiovascular diseases, metabolic syndrome, and renal function. The urinary albumin-to-creatinine ratio (ACR) serves as a sensitive marker for kidney health and holds significant prognostic value in predicting cardiovascular risks, stroke, diabetes, and all-cause mortality. This article aims to explore the correlation between the AST/ALT ratio and ACR in chronic kidney disease, to utilize these two indicators for a comprehensive assessment of human health. Furthermore, by understanding their relationship, liver injury markers can be used to predict kidney conditions, thereby facilitating early clinical management for patients with kidney disease.

关 键 词：天门冬氨酸氨基转移酶 丙氨酸氨基转移酶 尿白蛋白 尿肌酐 相关性 应用 

分 类 号：R69[医药卫生—泌尿科学]