无创产前检测中胎儿游离DNA浓度的影响因素及临床应用研究进展  

Advances in the Influencing Factors and Clinical Application of Fetal Fraction of the Non-Invasive Prenatal Testing

作　　者：陈鹏宇 张铨富 

机构地区：[1]暨南大学第一临床医学院,广东 广州 [2]暨南大学附属深圳市宝安区妇幼保健院产科,广东 深圳

出　　处：《临床医学进展》2024年第10期1182-1192,共11页Advances in Clinical Medicine

摘　　要：无创产前检测(Non-Invasive Prenatal Testing, NIPT)自临床应用以来,因其方便快捷、无需侵入的特点于全球迅速开展。胎儿游离DNA浓度(Fetal Fraction, FF)是NIPT的质控参数,同时也可作为预测不良妊娠结局的重要指标。本文旨在分析总结FF的影响因素及与胎盘相关性不良妊娠结局的关系,以期发挥FF在临床应用中的价值。Non-invasive prenatal testing (NIPT) has been rapidly developed worldwide due to its characteristics, including convenience and non-invasive. Fetal fraction (FF) is a parameter of sample quality control for NIPT and can also be used as an important indicator for predicting adverse pregnancy outcomes. This article aims to analyze and summarize the influencing factors of FF and the relationship between FF with placenta-related adverse pregnancy outcomes, in order to exert the value of FF in clinical application.

关 键 词：无创产前检测 胎儿游离DNA浓度 妊娠结局 产前咨询 

分 类 号：R71[医药卫生—妇产科学]