月经初潮年龄与疾病风险的孟德尔随机化研究进展  

Advances in Mendelian Randomization Studies on the Association between Age at Menarche and Disease Risk

作　　者：司振民 常惠[2] 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第一医院妇科一科,黑龙江 哈尔滨

出　　处：《临床医学进展》2024年第11期929-937,共9页Advances in Clinical Medicine

摘　　要：月经初潮年龄是女性青春期第一次出现子宫内膜出血的年龄,越来越多的研究表明月经初潮年龄与某些疾病风险有关系。孟德尔随机化研究是一种使用已知的暴露遗传决定因素来测试或估计暴露对疾病结果的因果影响的方法,可用于提供这些关联是否存在因果关系的证据。本文总结了先前使用孟德尔随机化方法研究月经初潮年龄与某些疾病风险的关系的研究,旨在描述孟德尔随机化研究如何帮助我们理解月经初潮年龄的因果关系,以期为临床医生提供新的思考。The age of menarche is the age at which endometrial bleeding first appears during female puberty, and more and more studies have shown that the age of menarche is associated with the risk of certain diseases. Mendelian randomization studies, a method that uses known genetic determinants of exposure to test or estimate the causal effect of exposure on disease outcomes, can be used to provide evidence of whether these associations are causal. This review summarizes previous studies using Mendelian randomization to study the relationship between age at menarche and the risk of certain diseases, and aims to describe how Mendelian randomization studies can help us understand the causality of age at menarche, with a view to providing new thinking for clinicians.

关 键 词：月经初潮年龄 孟德尔随机化研究 研究进展 

分 类 号：R71[医药卫生—妇产科学]