丹参及其主要成分对肺纤维化作用机制的研究进展  

Research Progress on the Mechanism of Action of Salvia miltiorrhiza and Its Main Components on Pulmonary Fibrosis

作　　者：张少琪 杨善军[1] 

机构地区：[1]黑龙江中医药大学附属第二医院肺病科,黑龙江 哈尔滨

出　　处：《临床医学进展》2024年第11期1228-1234,共7页Advances in Clinical Medicine

摘　　要：肺纤维化是由于肺组织遭到破坏,正常结构被大量纤维细胞所取代,并产生由胶原蛋白等组成的细胞外基质,影响肺通气功能,导致呼吸困难等一系列症状,极大地影响了人体健康与日常生活。其病因未完全明确,且目前临床治疗手段较为有限,效果不佳。因此,寻找有效且安全的治疗药物是研究的主要方向。丹参是一味活血化瘀的佳品,现已从中提取出多种有效药理成分如丹参素、丹参酮IIA、丹参酚酸、隐丹参酮等,可通过作用于多种信号机制,以此抑制肺纤维化的形成。本文对现有相关研究进行综合整理,以期为今后丹参应用于肺纤维化的临床治疗提供可靠的理论依据。Pulmonary fibrosis is caused by the destruction of lung tissue, where the normal structure is replaced by a large number of fibroblasts and an extracellular matrix composed of collagen is produced, which affects lung ventilation function and leads to a series of symptoms such as breathing difficulties, greatly affecting human health and daily life. The etiology is not fully understood, and currently clinical treatment methods are limited, resulting in poor efficacy. Therefore, finding effective and safe therapeutic drugs is the main direction of research. Salvia miltiorrhiza is a great herb for promoting blood circulation and removing blood stasis. Various effective pharmacological components have been extracted from it, such as danshensu, tanshinone IIA, salvianolic acid, cryptotanshinone, etc. It can inhibit the formation of pulmonary fibrosis by acting on various signaling mechanisms. This article comprehensively summarizes existing relevant research in order to provide reliable theoretical basis for the clinical treatment of pulmonary fibrosis using Danshen in the future.

关 键 词：丹参 肺纤维化 作用机制 

分 类 号：R28[医药卫生—中药学]