膏方治疗慢性阻塞性肺疾病的系统评价和Meta分析  

A Systematic Review and Meta-Analysis of Ointment for the Treatment of Chronic Obstructive Pulmonary Disease

作　　者：田欢欢 周海涛 陈思丞 程序 黄学宽[1] 

机构地区：[1]重庆医科大学中医药学院,重庆 [2]重庆医科大学第二临床学院,重庆 [3]重庆市垫江县中医院呼吸与危重症医学科,重庆

出　　处：《临床医学进展》2024年第11期184-194,共11页Advances in Clinical Medicine

摘　　要：目的:系统全面探讨膏方辅助治疗慢性阻塞性肺疾病(COPD)的临床及其相关Meta分析。方法:检索国内外中英文数据库近五年关于膏方治疗COPD的随机试验(RCT),利用Revman 5.3软件开展偏倚风险评价和Meta分析。结果:共纳入22篇文献、研究对象1745例,包括治疗组876例,对照组869例,Meta分析结果表明:与单一西药疗法比较,膏方增强总有效率(TE) [OR = 3.64, 95% CI (2.36, 5.59), P Objective: To systematically and comprehensively investigate the clinical and related Meta-analyses of the adjuvant treatment of chronic obstructive pulmonary disease (COPD) with plaster formula. Methods: Randomized trials (RCTs) of plaster prescriptions for the treatment of COPD in the past five years were searched in Chinese and English databases at home and abroad, and risk of bias assessment and Meta-analysis were carried out using Revman 5.3 software. Result: A total of 22 articles and 1745 study subjects were included, including 876 cases in the treatment group and 869 cases in the control group, and the results of Meta-analysis showed that compared with a single Western drug therapy, the total effective rate (TE) was enhanced by the plaster formula [OR = 3.64, 95% CI (2.36, 5.59), P < 0.00001], increased the percentage of forced expiratory volume in 1 second to predicted value (FEV1%) [MD = 4.91, 95% CI (3.39, 6.43), P < 0.00001], reduced the number of acute exacerbations [MD = −0.34, 95% CI (−0.39, −0.28), P < 0.00001], and the adverse effects were mild and few. Conclusion: The addition of ointment in the treatment of COPD can significantly improve the overall physiological indexes of patients, including alleviating respiratory symptoms, and enhancing patients’ exercise ability and immunity, and has no obvious side effects, therefore, it is recommended to use ointment as an adjuvant drug for COPD, and ensure the safety and effectiveness of the drug through large-scale, high-precision, and multi-point monitoring experiments.

关 键 词：慢性阻塞性肺疾病 膏方 随机对照试验 系统评价 META分析 

分 类 号：R56[医药卫生—呼吸系统]