阿立哌唑治疗帕利哌酮引起高泌乳素血症机制及研究进展  

The Mechanism and Research Progress of Aripiprazole in the Treatment of Hyperprolactinemia Caused by Paliperidone

作　　者：刘剑锋 孙亚东 戴尊孝[1,4] 

机构地区：[1]西安医学院,研究生处,陕西 西安 [2]西安市精神卫生中心,早期干预一科,陕西 西安 [3]西安市精神卫生中心,妇女心理卫生一科,陕西 西安 [4]西安市精神卫生中心,院长办公室,陕西 西安

出　　处：《临床医学进展》2024年第12期569-574,共6页Advances in Clinical Medicine

摘　　要：精神分裂症是一种致残率较高的慢性疾病。帕利哌酮是常用的抗精神病药物,高泌乳素血症是使用帕利哌酮时常见的副作用。在这种情况下,联合使用阿立哌唑可以有效降低泌乳素水平。因此,了解高泌乳素血症的产生机制、帕利哌酮导致高泌乳素血症的机制以及阿立哌唑降低泌乳素水平的作用机制,对于改善患者的生存质量尤为重要。本文综述了阿立哌唑治疗帕利哌酮引起的高泌乳素血症的机制,旨在探索有效的精神专科治疗方案。Schizophrenia is a chronic disease with a high morbidity rate. Paliperidone is a commonly used antipsychotic drug;however, hyperprolactinemia is a common side effect of paliperidone. In this setting, coadministration with aripiprazole may be effective in reducing prolactin levels. Therefore, understanding the mechanism of hyperprolactinemia, the mechanism of paliperidone causing hyperprolactinemia, and the mechanism of aripiprazole reducing prolactin levels is particularly important to improve the quality of life of patients. This article reviews the mechanism of aripiprazole in the treatment of paliperidone-induced hyperprolactinemia, aiming to explore effective psychiatric treatment options.

关 键 词：精神分裂症 高泌乳素血症 帕利哌酮 阿立哌唑 

分 类 号：R97[医药卫生—药品]