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出 处:《临床医学进展》2024年第12期650-659,共10页Advances in Clinical Medicine
摘 要:随着平均预期寿命的延长,女性有超过三分之一的生命处于绝经状态,围绝经期性激素水平波动及绝经后雌激素缺乏,引发机体诸多变化,引起令人困扰的更年期症状,亟需干预以提高女性福祉和生活质量。当前,激素补充疗法虽已被证实有效,但其存在适应症、禁忌症及慎用情况,不是所有患者都适用。因此需要更多可供选择的治疗方案,其中植物制剂黑升麻提取物被发现能有效缓解绝经症状,是激素补充治疗的合理替代药物。本综述旨在阐述和总结黑升麻提取物用于管理绝经女性健康的研究现状、有效性、安全性及作用机制。With the increase of average life expectancy, women spend over one-third of their lives in the menopausal state. Fluctuations in sex hormone levels during the perimenopausal period and estrogen deficiency after menopause trigger numerous changes in the body, causing bothersome menopausal symptoms. There is an urgent need for intervention to enhance women’s well-being and quality of life. Currently, although hormone replacement therapy has been proven effective, it has indications, contraindications and caution, and is not suitable for all patients. There is a need for more treatment options, among which the plant preparation black cohosh extract has been found to be effective in alleviating menopausal symptoms and is a reasonable alternative to hormone replacement therapy. This review aims to describe and summarize the research status, efficacy, safety and mechanism of Cimicifuga racemosa used to manage the health of menopausal women.
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