OX-2膜糖蛋白对冠心病合并糖尿病患者IL-6表达的影响  

The Effect of OX-2 Membrane Glycoprotein on the Expression of IL-6 in Patients with Coronary Heart Disease Combined with Diabetes

作　　者：杜世杰 刘成华 

机构地区：[1]山东第一医科大学(山东省医学科学院)研究生部,山东 济南 [2]山东第一医科大学附属临沂市中心医院心血管内科,山东 临沂

出　　处：《临床医学进展》2024年第12期1539-1544,共6页Advances in Clinical Medicine

摘　　要：目的:探讨OX-2膜糖蛋白(CD200)对冠心病合并糖尿病患者体内慢性炎症的调控作用。方法:选取2023年3月~2024年3月在临沂市中心医院就诊的符合纳入标准的冠心病患者、糖尿病患者、冠心病合并糖尿病患者3组各20例共60例,ELISA法检测各组患者血清中CD200分子浓度,流式细胞术测定血清中白细胞介素-6 (interleukin-6, IL-6)水平,对两组数据进行统计学分析比较,进而探究CD200对慢性炎症的抑制性调控作用。结果:冠心病患者、糖尿病患者、冠心病合并糖尿病患者3组数据均高于正常参考值(0~5.3 mmol/L),冠心病合并糖尿病组IL-6 (16.53 ± 3.88 mmol/L)水平高于冠心病组IL-6 (13.91 ± 1.70 mmol/L),差异有统计学意义(P Objective: To explore the regulatory effect of OX-2 membrane glycoprotein (CD200) on chronic inflammation in patients with coronary heart disease (CHD) complicated with diabetes mellitus (DM). Methods: A total of 60 patients were enrolled in this study, including 20 patients with CHD, 20 patients with DM, and 20 patients with CHD complicated with DM, all of whom met the inclusion criteria. The concentration of CD200 molecules in the serum of each group was determined by ELISA, and the level of IL-6 in the serum was measured by flow cytometry. The two sets of data were analyzed and compared to investigate the inhibitory regulatory effect of CD200 on chronic inflammation. Results: The data from the three groups of patients with coronary heart disease (CHD), diabetes mellitus (DM), and CHD complicated with DM were all higher than the normal reference values (0~5.3 mmol/L). The level of IL-6 in the CHD complicated with DM group (16.53 ± 3.88 mmol/L) was significantly higher than that in the CHD group (13.91 ± 1.70 mmol/L), with a statistically significant difference (P < 0.01). The level of IL-6 in the CHD complicated with DM group (16.53 ± 3.88 mmol/L) was also significantly higher than that in the DM group (15.70 ± 5.24 mmol/L), with a statistically signific

关 键 词：冠状动脉粥样硬化性心脏病 糖尿病 慢性炎症 白细胞介素-6 OX-2膜糖蛋白 

分 类 号：R54[医药卫生—心血管疾病]