TEG在过敏性紫癜患儿凝血功能及病情评估中的应用研究  

Study on the Application of Thromboelastography in the Assessment of Coagulation Function and Condition of Children with Henoch-Schönlein Purpura

作　　者：盛洁 孙礼宾[1] 

机构地区：[1]安徽医科大学附属巢湖医院普儿科,安徽 合肥

出　　处：《临床医学进展》2025年第1期2212-2220,共9页Advances in Clinical Medicine

摘　　要：目的:探讨血栓弹力图(TEG)对过敏性紫癜患儿凝血功能的评价作用及其病情严重程度评估方面的意义。方法:选取2023年4月~2024年8月在我院儿科收治的符合标准的44例过敏性紫癜患者为病例组,同时选择我院门诊健康体检的儿童42例作为对照组,对两组进行TEG与常规凝血检测,并对病例组进行紫癜症状评分,对比两组的检测结果差异,探讨病例组TEG各项参数与常规凝血功能指标的关联性及敏感性,评估各参数与病情的相关性。结果:相较于对照组,病例组的α角、MA值、LY30、Fib及D-D水平显著升高,而R值和K值则显著降低,以上差异均具有统计学意义(P α角呈正相关关系(r = 0.36, P r=−0.34, P r = 0.32, P r = 0.52, P α角评价HSP高血凝状态敏感性显著高于传统凝血指标Fib,在纤溶亢进状态的检出率方面,D-二聚体敏感性高于TEG参数LY30。α角、D-二聚体与紫癜症状评分均呈正相关(r = 0.827, P r = 0.320, P r = −0.588, P Objective: To investigate the role of thromboelastography (TEG) in the assessment of coagulation in children with Henoch-Schönlein purpura (HSP) and its relevance to the assessment of disease severity. Methods: 44 patients with HSP admitted to the Pediatrics Department of our hospital from April 2023 to August 2024 who met the criteria were selected as the case group, and 42 children who underwent outpatient health checkups in our hospital were selected as the control group, and TEG and Conventional coagulation test (CCT) were performed on the two groups and purpura symptom scoring was performed on the case group, and the differences in the results between the two groups were compared to explore the correlation and sensitivity of the various parameters of TEG and conventional coagulation test of the case group, and to assess the correlation between each parameter and the condition. The correlation between the indexes of thromboelastography in the case group and the indexes of Conventional coagulation t

关 键 词：过敏性紫癜 血栓弹力图 凝血功能 常规凝血检测 儿童 

分 类 号：R72[医药卫生—儿科]