系统性红斑狼疮患者外周血Zonulin检测的临床意义  

Clinical Significance of Zonulin Testing in Peripheral Blood in Patients with Systemic Lupus Erythematosus

作　　者：初小迪 刘又维 赵娜娜 李淑亚 邢倩[3] 

机构地区：[1]青岛大学青岛市市立医院,山东 青岛 [2]山东第二医科大学临床医学院,山东 潍坊 [3]康复大学青岛市市立医院,山东 青岛

出　　处：《临床医学进展》2025年第2期278-285,共8页Advances in Clinical Medicine

摘　　要：目的:为探究外周血Zonulin在评估系统性红斑狼疮(SLE)患者肠道通透性、疾病活动度以及受累脏器的临床价值。方法:共纳入60名SLE女性患者,通过ELISA测量血清连蛋白(Zonulin)及脂肪酸结合蛋白(IFABP)水平,并收集系统性红斑狼疮疾病活动指数(SLEDAI-2k)评分及临床指标评估疾病活动度,通过线性回归和Pearson相关性评估外周血Zonulin、IFABP水平与SLEDAI-2k及临床指标之间的相关性。结果:SLE患者中外周血Zonulin (p p p p 2 = 0.5247, p p p Objective: To explore the clinical value of peripheral blood Zonulin in the evaluation of intestinal permeability, disease activity, and affected organs in patients with systemic lupus erythematosus (SLE). Methods: 60 female patients with SLE were enrolled. Serum levels of Zonulin and intestinal fatty acid-binding protein (IFABP) were measured by ELISA. The SLE Disease Activity Index (SLEDAI-2k) score and clinical indicators were collected to assess disease activity. Linear regression and Pearson correlation were used to evaluate the correlations between Zonulin, IFABP in peripheral blood and SLEDAI-2k, clinical indicators. Results: Compared to healthy controls, the levels of Zonulin (p p p p 2 = 0.5247, p p p < 0.001) was negatively correlated. However, there was no statistically significant difference in Zonulin and IFABP levels in peripheral blood among patients with different organ involvements. Conclusion: Zonulin in peripheral blood may be associated with disease activity and exacerbation, potentially serving as a biomarker for the severity and progression of SLE, but it is unrelated to the involved organs and systems.

关 键 词：系统性红斑狼疮 肠道通透性 ZONULIN SLEDAI-2k 

分 类 号：R59[医药卫生—内科学]