雷公藤治疗动脉粥样硬化的作用机制研究进展  

Research Progress on the Mechanisms of Action of Tripterygium wilfordii Hook.f in the Treatment of Atherosclerosis

作　　者：王超英 陈会君[2] 

机构地区：[1]黑龙江中医药大学第二临床医学院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第二医院心血管科,黑龙江 哈尔滨

出　　处：《临床医学进展》2025年第2期554-562,共9页Advances in Clinical Medicine

摘　　要：动脉粥样硬化会出现血管内皮损伤,纤维组织增生,脂质沉积、钙质沉着于血管壁,逐渐形成斑块,造成管腔狭窄。动脉粥样硬化主要侵犯大中型动脉血管,是多种心血管疾病病理基础。其病死率呈现下降趋势,但发病率仍在不断增加,所以动脉粥样硬化的预防和治疗仍需重视。雷公藤具有多种活性成分,可通过调节免疫系统、炎症反应、线粒体功能、氧化应激、脂质代谢、血小板功能、血管重塑以及抗血栓形成等多个途径起到抗动脉粥样硬化的作用。雷公藤因其具有多成分、多途径、多靶点、整体性的特点,可更有效抑制动脉粥样硬化对血管的损伤。文章的意义在于系统总结了雷公藤治疗动脉粥样硬化的潜在机制,为雷公藤的临床应用和新药研发提供了理论依据。Atherosclerosis is characterized by endothelial injury, proliferation of fibrous tissue, lipid deposition, and calcium accumulation in the vascular wall, gradually forming plaques that lead to lumen narrowing. Atherosclerosis mainly invades large and medium-sized arterial vessels, and is the pathological basis of many cardiovascular diseases. Its death rate shows a decreasing trend, but the incidence is still increasing, so the prevention and treatment of atherosclerosis still need attention. Tripterygium wilfordii Hook.f has a variety of active components, which can play an anti-atherosclerotic role by regulating the immune system, inflammatory response, mitochondrial function, oxidative stress, lipid metabolism, platelet function, vascular remodeling, and anti-thrombosis in a number of pathways. Because of its multi-component, multi-pathway, multi-target and holistic characteristics, Tripterygium wilfordii Hook.f can more effectively inhibit the damage of atherosclerosis on blood vessels. The significance of the article is that it systematically summarizes the potential mechanism of Tripterygium wilfordiiHook.f in the treatment of atherosclerosis, and provi

关 键 词：雷公藤 机制 动脉粥样硬化 研究进展 

分 类 号：R28[医药卫生—中药学]