2型糖尿病合并代谢相关脂肪性肝病患者的脂肪相关指标、四肢骨骼肌质量校正值与肝脏脂肪变性相关性分析  

Correlation Analysis of Fat-Related Indicators, Limb Skeletal Muscle Mass Correction Values and Liver Steatosis in Patients with Type 2 Diabetes Mellitus Complicated with Metabolic-Related Fatty Liver Disease

作　　者：崔亚迪 何雨晴 席爽 孔郁鸿 卢冬旭 吴韬[2] 

机构地区：[1]河北医科大学研究生学院,河北 石家庄 [2]石家庄市人民医院内分泌科,河北 石家庄

出　　处：《临床医学进展》2025年第2期606-617,共12页Advances in Clinical Medicine

摘　　要：目的:探究2型糖尿病(T2DM)合并代谢相关脂肪性肝病(MAFLD)患者的脂肪、四肢骨骼肌质量指数与肝脏脂肪变性程度的相关性。方法:选取2023年9月至2024年9月于石家庄市人民医院内分泌科住院接受治疗18~75岁T2DM合并MAFLD患者共200例。根据代表肝脏脂肪变性的严重程度的受控衰减参数(CAP)水平(S0: CAP Objective: To investigate the correlation between fat, limb skeletal muscle mass index and liver steatosis in patients with type 2 diabetes mellitus (T2DM) and metabolic-associated fatty liver disease (MAFLD). Methods: A total of 200 patients with T2DM and MAFLD aged 18~75 years who were hospitalized in the Department of Endocrinology of Shijiazhuang People’s Hospital from September 2023 to September 2024 were selected. According to the level of controlled attenuation parameter (CAP) representing the severity of hepatic steatosis (S0: CAP < 238 dB/m, S1: 238 dB/m ≤ CAP < 260 dB/m, S2: 260 dB/m ≤ CAP < 292 dB/m, S3: CAP ≥ 292 dB/m), the patients were divided into 88 cases of non-severe hepatic steatosis group and 112 cases of severe hepatic steatosis group. All patients were measured visceral fat grade (VFG), body mass index (BMI), body fat mass (FM), body fat percentage (BF%), limb skeletal muscle mass (ASM), fat mass index (FMI), limb skeletal muscle mass positive college value (ASMI), limb skeletal muscle mass weight correction value (ASM/W), instantaneous elasticity imaging parameters CAP value (dB/m) and other indicators. Results: 1) VFG, BMI, BF %, FM, FMI, ASMI, HOMA-IR, TG and ALT in severe hepatic steatosis group were higher than those in non-severe hepatic steatosis group, while ASM/W was significantly lower than that in non-severe hepatic steatosis group (P < 0.05). 2) Pearson/Spearman correlation analysis showed that CAP was positively correlated with VFG, BMI, BF %, FM, FMI, ASMI, FINS, HOMA-IR and ALT (r = 0.302, 0.547, 0.470, 0.581, 0.580, 0.183, 0.420, 0.429, 0.354, P < 0.05), and CAP was negatively correlated with A

关 键 词：2型糖尿病 代谢相关脂肪性肝病 脂肪质量指数 四肢骨骼肌质量指数 

分 类 号：R58[医药卫生—内分泌]