糖尿病足溃疡发病机制研究进展  

Progress in the Pathogenesis of Diabetic Foot Ulcer

作　　者：钱洪发 张韵凯 吴亮[1] 

机构地区：[1]中国药科大学新药筛选中心,江苏 南京

出　　处：《生物过程》2019年第4期29-35,共7页Bioprocess

摘　　要：正常状况下,伤口愈合是一个动态且复杂的过程,包括凝血,炎症,增殖以及重塑四个阶段,涉及多种细胞、细胞因子、细胞外成分以及生长因子间的相互作用。糖尿病患者由于血糖异常等多种因素,导致伤口愈合的一个或多个阶段受到抑制,因而愈合缓慢,可能发展成为糖尿病足溃疡。同时,糖尿病足溃疡是一种致残性溃疡,患者截肢及死亡率很高。鉴于糖尿病患者伤口愈合的复杂性,本文综述了伤口愈合不同阶段的特点,以及糖尿病伤口愈合的病理生理学机制,为糖尿病足溃疡的治疗提供切入点。Under normal conditions, wound healing is a dynamic and complex processincluding hemostasis, inflammation, proliferation, and remodeling, involving avariety of cells, extracellular components, growth factors, and cytokineinteractions. In diabetic patients, one or more stages of wound healing areinhibited due to various factors such as abnormal blood glucose, thus woundsheal slowly and may develop into diabetic foot ulcers. Diabetic foot ulcers area type of disabling ulcer that causesamputation and a high mortality rate. In view of the complexity of woundhealing in diabetic patients, this paper summarized the characteristics ofdifferent stages of wound healing and the pathophysiological mechanism of woundhealing in diabetic patients, so as to provide a starting point for thetreatment of diabetic foot ulcer.

关 键 词：糖尿病足 伤口愈合 溃疡 发病机制 

分 类 号：R58[医药卫生—内分泌]