涡虫肌肉系统再生研究进展  

Research Progress in Nervous Regeneration of Planarians

作　　者：朱纯霄 乌尼尔夫[3] 曹俊伟[1,2] 周欢敏 张焱如[1,2] 刘春霞 

机构地区：[1]内蒙古农业大学生命科学学院,内蒙古 呼和浩特 [2]内蒙古自治区生物制造重点实验室,内蒙古 呼和浩特 [3]内蒙古农业大学动物医学学院,内蒙古 呼和浩特

出　　处：《生物过程》2021年第3期30-37,共8页Bioprocess

摘　　要：涡虫结构简单,具有极强的再生能力。再生,是指机体受损后,细胞、组织和器官的修复,并重建适当的组织极性、结构。在同一动物的不同组织中可以采用多种模式。当受到创伤后,涡虫的任意部位均可以再生出完整的个体。这种强大的再生能力是由neoblast介导的,neoblast是一种含有多能干细胞的增殖细胞群,具有异质性。涡虫具有明显的极性,受损后,严格按照前后轴、背腹轴、左右轴进行再生。涡虫有发达的体壁肌肉组织,在整个有机体内形成复杂的肌肉网络。涡虫的体壁肌肉细胞产生的位置信息基因(position control genes, PCGs),在再生过程中控制前后模式,对干细胞介导的组织替换和再生起着重要的指导作用。文章讨论了涡虫肌肉再生以及肌肉与极性基因之间的联系。The planarian has a simple structureand strong regeneration ability. Regeneration refers to the repair of cells,tissues and organs and the reconstruction of appropriate tissue polarity,structure, and form. Multiple models can be used in different tissues of thesame animals. When traumatized, planarians can regenerate intact organisms.This powerful regeneration ability is mediated by neoblast, a kind ofproliferation cell population containing pluripotent stem cells withheterogeneity. After being damaged, the planarian regenerates in strictaccordance with the anteroposterior axis, dorsal ventral axis and left andright axis. Planarian has developed muscle tissue of body wall, forming complexmuscle network in the whole organism. The signal molecules produced by themuscle cells in the body wall of planarians control the pre- and post-modescells in the process of regeneration. Positional information genes (PCGs)mainly exist in muscle tissue and play an important role in guiding stemcell-mediated tissue replacement and regeneration. Muscle regeneration and therelationship between muscle and polar genes were discussed.

关 键 词：肌肉 极性 NEOBLAST 涡虫 

分 类 号：Q95[生物学—动物学]