基于壳聚糖导管的周围神经再生研究进展  

Research Progress of Peripheral Nerve Regeneration Based on Chitosan Catheter

作　　者：王钰清 魏静静 李文慧 张鲁中[1] 杨宇民[1] 

机构地区：[1]南通大学,教育部/江苏省神经再生重点实验室/神经再生协同创新中心,江苏 南通

出　　处：《生物过程》2022年第2期148-153,共6页Bioprocess

摘　　要：如何促进周围神经损伤修复是一个棘手的临床难题,特别是长距离周围神经缺损。近年来随着材料科学的发展,已有多种不同材料制造的神经导管被用于治疗周围神经缺损,其中,壳聚糖由于其优良的生物性能而被广泛应用,研究表明联合使用各种可促神经再生的物质,可进一步提高治疗效果。本文就基于壳聚糖导管的混合策略、细胞接种、生物因子负载三个方面展开阐述。How to promote the repair ofperipheral nerve injury is a difficult clinical problem, especially for long-distanceperipheral nerve defect. In recent years, with the development of materialsscience, nerve catheters made of various materials have been used to treatperipheral nerve injury, among which chitosan has been widely used due to itsexcellent biological properties. Studies have shown that the combined use ofvarious substances that can promote nerve regeneration can further improve thetherapeutic effect. In this paper, the mixing strategy, cell inoculation andbiological factor loading based on chitosan catheter are described.

关 键 词：周围神经再生 壳聚糖 导管 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]