蛋白质组学技术在中药研究中的应用进展  

Progress in the Application of Proteomics Technology in Traditional Chinese Medicine Research

作　　者：张晓嫣 王琦鑫 商瑜[1] 刘进[1] 黄凌云[1] 

机构地区：[1]北京师范大学生命科学学院细胞增殖及调控生物学教育部重点实验室,北京

出　　处：《生物过程》2023年第4期187-194,共8页Bioprocess

摘　　要：中药于我国历史悠久,时至今日,其依旧有着不可替代的药用价值。中药相较于化学合成药物,其由生物体自身产生,在结构多样性、活性独特性等方面作用优异。然而,由于中药成分复杂,相关作用机理的研究一直是限制中药发展的一道关键难题。蛋白质组学技术能够从整体上把握机体生理、病理和信号传导途径,这恰与中药多靶点作用的特点相契合。越来越多有关中药作用机理的研究应用到蛋白质组学技术,我们对作用机理、药效及安全性等问题的理解不断深入,以求打破中药发展障碍,为之更好的应用提供可能性。本文结合相关文献,简要介绍蛋白质组学研究技术以及在中药作用效果和作用机制等方面的应用进展。Traditional Chinese medicine has a long history in China, and it still has irreplaceable medicinal value today. Compared with chemosynthetic drugs, traditional Chinese medicines are produced by the organism itself and have excellent functions in structural diversity and activity uniqueness. However, due to the complex composition of traditional Chinese medicine, the study of related mechanism has been a key problem that restricts the development of traditional Chinese medicine. Proteomics can help understand the physiological, pathological and signal transduction pathways of the body as a whole, which is in line with the characteristics of multitarget role of traditional Chinese medicine. More and more researches on the mechanism of action of traditional Chinese medicine have been applied to proteomics, and our understanding of the mechanism of action, efficacy and safety of traditional Chinese medicine has been deepened, so as to break down the barriers to the development of traditional Chinese medicine and provide possibilities for its better application. This paper combines relevant literature to briefly introduce proteomics research techniques and their research applications in the effects and mechanisms of traditional Chinese medicine.

关 键 词：蛋白质组学 作用机制 中药 

分 类 号：R28[医药卫生—中药学]