m6A修饰在砷诱导毒效应中发挥的作用研究进展  

Research Progress on the Role of m6A Modification in Arsenic-Induced Toxicity

作　　者：李仁杰 

机构地区：[1]重庆医科大学公共卫生学院,重庆

出　　处：《生物过程》2024年第2期56-63,共8页Bioprocess

摘　　要：在环境领域中,砷是一种有毒的重金属,主要通过饮用水途径对人类健康造成各种影响。如今,全球约2亿人正受到含砷的饮用水影响,是一个亟待解决的全球性公共卫生问题。N6-甲基腺苷(m6A)修饰是哺乳动物mRNA中最丰富的化学修饰,在越来越多的研究中发现m6A修饰参与了砷诱导毒效应,因此研究异常RNA修饰在重金属毒性中的作用和机制是一个非常有前景的领域。本研究通过参考国内外文献,综述了m6A修饰在砷诱导毒效应中发挥的作用,并为今后探索其它重金属的毒效应机制提供研究方向。In the environmental field, arsenic is a toxic heavy metal that causes various effects on human health mainly through the drinking water route. Today, about 200 million people are exposed to arsenic from drinking water, which is a global public health problem that needs to be addressed urgently. N6-methyladenosine (m6A) modification is the most abundant chemical modification in mammalian mRNA. More and more studies have found that m6A modification is involved in arsenic-induced toxicity, so studying the role and mechanism of abnormal RNA modification in heavy metal toxicity is a very promising field. This paper reviews the role of m6A modification in arsenic-induced toxicity by referring to domestic and foreign literature, and provides research directions for exploring the toxic mechanism of other heavy metals in the future.

关 键 词：砷 m6A修饰 毒效应 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]