壳聚糖酰基化衍生物的合成及其两亲性研究  

Fabrication and Amphiphilicity of Acylated Chitosan Derivatives

作　　者：关怀民[1] 张新丽 阚巡 廖梦廉 林俊炎 童跃进[1] 

机构地区：[1]福建师范大学,化学与材料学院,福建福州

出　　处：《化学工程与技术》2019年第2期117-125,共9页Hans Journal of Chemical Engineering and Technology

基　　金：福建省自然科学基金资助项目(2016J01044)。

摘　　要：本文从壳聚糖结构特点出发,采用氨基保护法在羟基上引入长链疏水性基团合成三种不同两亲性能的壳聚糖酰基化衍生物,红外光谱(FT-IR)和核磁共振氢谱(1H NMR)证实了两亲二硬脂酰基壳聚糖酯的化学结构。利用Langmiu-Blodgett槽制备两亲二硬脂酰壳聚糖酯单分子层,通过对二硬脂酰壳聚糖酯Langmiur膜的表面压–单分子层表观面积(π-A)等温曲线分析表明,硬酯酰基取代度4.8的二硬脂酰壳聚糖酯(DSCS-4.8)具有较强的两亲性,能形成稳定致密的Langmiur单分子膜,且Langmiur单分子膜的平均单分子极限表面积等于268.75 cm2,崩溃压等于44.35 mN/m。三种二硬酯酰壳聚糖酯对水的静态接触角随着两亲性的增加而增大。通过LB技术将单分子膜转移制备多层膜修饰的硅片。The acylated chitosan,distearyl chitosan,was synthesized by the selective protection of amino groups in MeSO3H,and characterized by means of Fourier translation infrared spectroscopy(FT-IR),nuclear magnetic resonance hydrogen spectrum(1H NMR)and water contact angle measurements.The preparation of the distearyl chitosan monolayer was carried out and amphiphilic behavior was investigated via Langmuir technique.By analyzing surface pressure-area(π-A)isotherm,the condensed distearyl chitosan monolayer fabricated at air-water interface had a collapse pressure of 44.35 mN/m and the average limited area(A*)of 268.75 cm2,indicating the formation of the stable Langmuir monolayer.Furthermore,the distearyl chitosan monolayer was successfully transferred onto Si electrode by Langmuir-Blodgett technique.

关 键 词：二硬脂酰壳聚糖酯 两亲性 Langmiur膜 

分 类 号：O62[理学—有机化学]