芦笋提取物安全性评价研究  

Safety Evaluation of Asparagus Extract

作　　者：杨文祥[1,2] 田辉 邬源泉[1,2] 樊军 郑艳华 王利霞[1,2] 

机构地区：[1]湖北省疾病预防控制中心,湖北 武汉 [2]湖北省应用毒理重点实验室,湖北 武汉

出　　处：《食品与营养科学》2023年第1期21-27,共7页Hans Journal of Food and Nutrition Science

摘　　要：目的:研究芦笋提取物作为食品的安全性。方法:小鼠急性口服毒性试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验和大鼠30天喂养试验。结果:小鼠急性口服毒性试验MTD值大于20 g/kg体重,小鼠骨髓嗜多染红细胞微核试验和精子畸形试验为阴性,以人群推荐剂量100倍大鼠口服30天,临床症状、血相生化、动物脏器和病理组织学检查指标均无变化。结论:芦笋提取物符合食品安全的毒理学要求。Purpose: To test the safety of asparagus extract as a kind of health food. Method: We obtained toxicology results through acute toxicity test, micronucleus test of bone mar-row cell, sperm shape abnormality test and thirty days feeding tests. Result: The MTD value of acute oral toxicity test in mice was more than 20 g/kg bw. The micronucleus tests of bone marrow poly-chromatic erythrocytes and sperm abnormality test in mice were negative, there were no changes in clinical symptoms, blood biochemistry, animal viscera and histopathology. Conclusion: Asparagus extract meets the toxicological requirements of food safety.

关 键 词：芦笋提取物 急性毒性 遗传毒性 30天喂养试验 

分 类 号：R28[医药卫生—中药学]