太子参多糖辅助降血糖保健功能评估  

Assessment of Health Care Function of the Pseudostellaria heterophylla Polysaccharide-Assisted Hypoglycemic

作　　者：吴华嵩 黄雅婷 阚永军 庞文生[2] 胡娟[2,3] 

机构地区：[1]福建省中医药科学院,比较医学中心,福建 福州 [2]福建中医药大学药学院,福建 福州 [3]福建中医药大学附属第二人民医院,药学部,福建 福州

出　　处：《食品与营养科学》2023年第3期252-257,共6页Hans Journal of Food and Nutrition Science

摘　　要：目的:对太子参多糖进行辅助降血糖功能试验及评价。方法:以四氧嘧啶诱导制备小鼠高血糖模型,太子参多糖100 mg/kg、200 mg/kg、400 mg/kg,高、中、低剂量每天一次,灌胃给药30天,必要时可延长至45天,测定小鼠空腹血糖和口服葡萄糖耐量。结果:高血糖动物模型灌胃30天后,太子参多糖的高剂量组的血糖值低于模型组有显著性差异(P < 0.01),中剂量组血糖值低于模型组有统计学差异(P < 0.05);太子参糖耐量实验,高剂量组与模型对照组比较,其血糖曲线下面积降低有显著性差异(P < 0.01);中、低剂量组与模型对照组比较,其血糖曲线下面积降低有统计学差异(P < 0.05)。结论:太子参多糖具有辅助降血糖保健功效。Objective: To test and evaluate the auxiliary hypoglycemic function of the Pseudostellaria heterophylla polysaccharide. Methods: Mouse hyper-glycemia model was prepared by alloxan induction, these dosages of polysaccharide at 100 mg/kg, 200 mg/kg, 400 mg/kg, that were high, medium and low doses. Once a day, given for 30 days, and extended to 45 days if necessary. Fasting blood glucose and oral glucose tolerance were determined. Results: After 30 days in hyperglycemia animal model, the blood glucose value in the high dose of the polysaccharide was lower than the model group (P < 0.01), and medium dose of the polysaccharide was lower than the model group (P < 0.05). In the glucose tolerance experiment, the high dose group was compared with the model control group, the reduced area under the glucose curve down was significantly different (P < 0.01). The reduced area under the glucose curve was statistically different between the medium and low dose groups and the model control group (P < 0.05). Conclusion: Pseudostellaria heterophylla polysaccharide has the effect of auxiliary hypoglycemic health care.

关 键 词：太子参多糖 辅助降血糖 保健功效 

分 类 号：R28[医药卫生—中药学]