鹅去氧胆酸的氧化产物合成  

The Synthesis of the Oxidation of Chenodeoxycholic Acid

作　　者：蔡烈峰 

机构地区：[1]杭州和泽医药科技有限公司,浙江杭州

出　　处：《药物化学》2015年第2期11-14,共4页Hans Journal of Medicinal Chemistry

摘　　要：目的:选择性氧化得到鹅去氧胆酸不同位置的氧化产物。方法:使用碳酸银作氧化剂得到3位羟基被氧化的产物;使用N-溴代丁二酰二胺作氧化剂得到7位羟基被氧化产物;使用琼斯试剂作氧化剂得到3位和7位羟基均被氧化的产物。结果:本工艺提供的选择性氧化方法成本更低,收率更高,后处理更方便,适合工业化生产。结论:本文所选择的方法具有条件温和,操作简单,成本低,收率高,适合工业化大生产的优点。Objective: Regioselective oxidation of chenodeoxycholic acid in different positions. Methods: The third was oxidized with silver carbonate;the seventh was oxidized with N-bromosuccinimide;the third and the seventh were oxidized with Jones reagent. Results: The synethesis of regioselective oxidation of chenodeoxycholic acid has advantages such as lower cost, higher yield, easier in aftertreatment and more suitable for industrialized production. Conclusion: This synthetic process has advantages such as mild conditions, easy operation, low cost and high yield, and is suitable for large-scale production.

关 键 词：鹅去氧胆酸 氧化 合成 

分 类 号：R28[医药卫生—中药学]