基于UPLC-Q-TOF-MS/MS技术快速鉴定截叶铁扫帚中化学成分  

Rapid Identification on Chemical Components in Lespedeza Cuneata by UPLC-Q-TOF-MS/MS

作　　者：朱高峰 陈瑞 王建塔 汤磊 

机构地区：[1]贵州医科大学,基础医学院,贵州 贵阳 [2]贵州省化学合成药物研发利用工程技术研究中心,贵州 贵阳

出　　处：《药物化学》2021年第2期35-43,共9页Hans Journal of Medicinal Chemistry

摘　　要：目的:应用液质联用技术和UNIFI分析软件对截叶铁扫帚的化学成分进行快速地定性分析。方法:在正负模式下采集数据,使用UNIFI数据处理系统进行识别,结合碎片离子、在线数据库系统和查阅相关文献,对主要的碎片离子峰进行结构确证。结果:本次实验共推断出82个化学成分。结论:该方法快速简便地分析出了截叶铁扫帚的化学成分,为下一步研究截叶铁扫帚的物质成分与作用机制奠定了理论基础。Objective: Rapid qualitative analysis of chemical constituents of Lespedeza cuneata by liquid chro-matography-mass spectrometry and UNIFI analysis software. Methods: Data were collected in posi-tive and negative modes and identified by UNIFI data processing system. The main fragment ion peaks were confirmed by combining with fragment ion, online database system and relevant liter-ature. Result: 82 chemical constituents were inferred in this experiment. Conclusion: This method can quickly and easily analyze the chemical constituents of Lespedeza cuneata, which lays a theo-retical foundation for the further research on the material composition and mechanism of Lespede-za cuneata.

关 键 词：截叶铁扫帚 液质联用 UNIFI 鉴定 化学成分 

分 类 号：R28[医药卫生—中药学]