3,5-取代-1,2,4-恶二唑类化合物的研究进展  

Research Progress of 3,5-Substituted-1,2,4-Oxadiazole Compounds

作　　者：孟祥东 RajendranSatheeshkumar 王文龙 

机构地区：[1]江南大学药学院,江苏 无锡

出　　处：《药物化学》2021年第2期67-77,共11页Hans Journal of Medicinal Chemistry

摘　　要：3,5-取代-1,2,4-恶二唑是一类重要的杂环化合物,作为脂键、酰胺键等常见化学键的生物电子等排体在药物化学领域有着重要应用价值,因此其合成方法也受到广泛关注。本文归纳总结了3,5-取代-1,2,4-恶二唑类化合物的合成研究进展,主要介绍了以氰基、酮醛、酰胺肟、酮肟、炔烃等为起始原料合成3,5-取代-1,2,4-恶二唑类化合物的研究进展及其反应机理。最后对该类化合物的合成研究进展进行了总结和展望。3,5-Substituted-1,2,4-oxadiazole is an important class of heterocyclic compounds. As the bio-isostere of common chemical bonds such as lipid bonds and amide bonds, it has important ap-plication value in the field of medicinal chemistry. Synthetic methods have also received wide-spread attention. This article summarizes the progress in the synthesis of 3,5-substituted-1,2,4-oxadiazole compounds, and mainly introduces the synthesis of starting mate-rials with cyano groups, ketone aldehydes, amide oximes, ketoximes, alkynes, etc. research pro-gress and reaction mechanism of 3,5-substituted-1,2,4-oxadiazole compounds. Finally, the research progress of the synthesis of these compounds is summarized and prospected.

关 键 词：1 2 4-恶二唑 合成 含氮杂环 酰胺肟 

分 类 号：O62[理学—有机化学]