邻硝基苯甲醛的制备与谱学分析  

Preparation and Spectroscopic Analyses of 2-Nitrobenzaldehyde

作　　者：江雨柔 苏丹 伍林玲 贾爱铨 张千峰 

机构地区：[1]安徽工业大学分子工程与应用化学研究所,安徽 马鞍山

出　　处：《药物化学》2022年第1期1-8,共8页Hans Journal of Medicinal Chemistry

摘　　要：邻硝基苯甲醛是重要的有机中间体,在有机合成和制药方面有着广泛的应用,本文首先合成N,N’-二甲基甲酰胺二甲基缩醛(DMFDMA),采用邻硝基甲苯与DMFDMA经缩合氧化合成邻硝基苯甲醛,并通过1H NMR、13C NMR、FT-IR等谱学手段对产物进行分析,总收率为88.03%、纯度高达99.07% (HPLC)。本合成生产工艺方法经济成本低,收率高,对环境污染小,相较于传统工艺有较为明显的优势。2-Nnitrobenzaldehyde is an important organic intermediate, which is widely used in organic syn-thesis and pharmaceutical fields. 2-Nitrobenzaldehyde was synthesized from N,N’-dimethylformamide dimethyl acetal (DMFDMA) by condensation oxidation. The isolated prod-uct was analyzed by 1H NMR, 13C NMR and FT-IR spectroscopic methods. The total yield was 88.03%, and the purity was as high as 99.07% (HPLC). The synthetic production process has the advantages of low economic cost, high yield and low environmental pollution, and has obvious advantages over the traditional process.

关 键 词：邻硝基苯甲醛 合成 N N’-二甲基甲酰胺二甲基缩醛 生产工艺 环保 

分 类 号：TQ460.4[化学工程—制药化工]