低银杏酚酸白果粉脱毒工艺优化  

Optimization of Detoxification Process for Low Ginkgo Phenolic Acid in Ginkgo Powder

作　　者：康津铭 王云春 樊恩生 刘鹏程 吴泽宇 惠爱玲 张文成 

机构地区：[1]合肥工业大学食品与生物工程学院农产品生物化工教育部工程研究中心,安徽 合肥 [2]江苏贝斯康药业有限公司,江苏 徐州

出　　处：《药物化学》2023年第2期41-49,共9页Hans Journal of Medicinal Chemistry

摘　　要：本文采用正己烷–乙醇混合溶剂降低银杏酚酸含量,建立一种低酚酸白果粉的工艺。作者探究了正己烷浓度、洗脱时间、洗脱温度单因素影响,并进一步通过响应面法优选出工艺参数:正己烷含量为16.69%,洗脱温度为41.73℃,洗脱时间为28.02 min,此条件下银杏酸含量 < 10 mg/kg,符合国家药典2020版标准。In this paper, n-hexane-ethanol mixed solvent was used to reduce the content of ginkgo phenolic acid, and a process design optimization idea for ginkgo powder with low phenolic acid was established. In the experiment of reducing phenolic acid content, the n-hexane concentration, elution time and elution temperature were investigated respectively. The optimal conditions for removing phenolic acid are obtained by response surface methodology: n-hexane content is 16.69%, the elution temperature is 41.73˚C, and the elution time is 28.02 min. Under this condition, the phenolic acid content is less than 10 mg/kg, which meets national pharmacopoeia 2020.

关 键 词：白果粉 银杏酚酸 工艺优化 

分 类 号：R28[医药卫生—中药学]