菲啶酮和吖啶酮类天然产物合成及生物活性研究进展  

Synthesis and Biological Activity Research Progress of Phenanthridinone and Quinolinone Natural Products

作　　者：马钰栋 张文渊 

机构地区：[1]兰州交通大学化学化工学院,甘肃 兰州

出　　处：《药物化学》2024年第2期101-117,共17页Hans Journal of Medicinal Chemistry

摘　　要：菲啶酮(Phenanthridinone)和吖啶酮(Acridone)是两类重要的生物碱类化合物,广泛存在于许多活性天然产物骨架中。本文综述了近年来菲啶酮和吖啶酮类天然产物在合成和生物活性方面的最新研究进展。首先,重点介绍了菲啶酮和吖啶酮类天然产物的生物活性,包括抗氧化、抗炎、抗肿瘤、抗菌和抗病毒等方面的活性,并对其作用机制进行了阐述。然后,介绍了菲啶酮和吖啶酮类天然产物的化学结构和分类,然后总结了它们的合成方法,包括传统的合成方法、新型的绿色合成方法以及催化下的合成方法。最后,指出了当前研究中存在的问题和未来的发展方向,为相关领域的研究提供了参考。Phenanthridinone and acridone are two important alkaloids that are widely present in many active natural product frameworks. In this paper, the recent advances in the synthesis and bioactivity of phenanthridone and acridone natural products were reviewed. Firstly, the biological activities of phenridone and acridone natural products, including antioxidant, anti-inflammatory, anti-tumor, antibacterial and antiviral activities, were introduced, and their mechanisms of action were described. Then, the chemical structure and classification of phenanthridone and acridone natural products were introduced, and their synthesis methods were summarized, including traditional synthesis methods, new green synthesis methods and catalytic synthesis methods. Finally, it points out the existing problems in the current research and the future development direction, and provides a reference for the research in related fields.

关 键 词：菲啶酮 吖啶酮 生物碱 合成 生物活性 

分 类 号：O62[理学—有机化学]