IMiDs作为PPI稳定剂在蛋白质降解方面的研究进展  

Research Progress of IMiDs as PPI Stabilizer in Protein Degradation

作　　者：宋冰茹 袁大中 

机构地区：[1]浙江师范大学化学与材料科学学院,浙江 金华

出　　处：《药物化学》2025年第1期49-60,共12页Hans Journal of Medicinal Chemistry

摘　　要：在过去的二十年里,随着IMiD和indisulam等MG降解剂的出现,分子胶(MGs)逐渐引起了制药界的关注。这些分子通过促进靶蛋白和E3连接酶之间的相互作用来降解靶蛋白。此外,MGs作为化学诱导剂,促进同源蛋白和异源蛋白的二聚化形成三元复合物,在调节生物活性方面具有很大的前景。本文重点介绍MGs在药物开发领域的应用,包括蛋白质–蛋白质相互作用(PPI)稳定性和蛋白质降解。我们深入分析了各种MGs的结构以及MGs与各种生物活性分子之间的相互作用,从而为PPI稳定剂和新型降解剂的开发提供了新的视角。Over the past two decades, molecular glues (MGs) have gradually attracted the attention of the pharmaceutical community with the advent of MG degraders such as IMiDs and indisulam. Such molecules degrade the target protein by promoting the interaction between the target protein and E3 ligase. In addition, as a chemical inducer, MGs promote the dimerization of homologous proteins and heterologous proteins to form ternary complexes, which have great prospects in regulating biological activities. This review focuses on the application of MGs in the field of drug development including protein-protein interaction (PPI) stability and protein degradation. We thoroughly analyze the structure of various MGs and the interactions between MGs and various biologically active molecules, thus providing new perspectives for the development of PPI stabilizers and new degraders.

关 键 词：蛋白质–蛋白质相互作用 分子胶 PPI稳定剂 降解剂 

分 类 号：O64[理学—物理化学]