羟基红花黄色素A保护心脏机制和药物吸收代谢  

Mechanism of Cardiac Protection and Drug Absorption and Metabolism of Hydroxysafflor Yellow A

作　　者：张丽琼 

机构地区：[1]兰州交通大学生物与制药工程学院,甘肃 兰州

出　　处：《药物化学》2025年第1期86-94,共9页Hans Journal of Medicinal Chemistry

摘　　要：羟基红花黄色素A (Hydroxysafflor yellow A, HSYA)属于查尔酮苷类化合物质,具有广泛的药理作用和生理活性,如扩张冠状动脉、抗氧化、保护心肌、降血压、免疫抑制和脑保护等多种药理功能。对心血管系统具有保护作用,但因羟基红花黄色素A是水溶性查尔酮,跨膜能力差,不易吸收,所以对提高其生物利用度显得尤为重要,本文梳理羟基红花黄色素A对心脏的保护作用和提高其生物利用度研究的最新进展。Hydroxysafflor A (Hydroxysafflor yellow A, HSYA) belongs to chalcone glycoside compounds, with a wide range of pharmacological effects and physiological activities, such as coronary expansion, antioxidant, myocardial protection, blood pressure reduction, immune suppression and brain protection and other pharmacological functions. It has a protective effect on the cardiovascular system, but because hydroxyl safflower A is water-soluble chalcone, its transmembrane ability is poor, and it is not easy to absorb, so it is particularly important to improve its bioavailability. This paper reviews the latest progress of the protective effect of hydroxyl safflower A on the heart and improving its bioavailability.

关 键 词：羟基红花黄色素A 心血管系统 生物利用度 

分 类 号：R28[医药卫生—中药学]