白内障术后黄斑囊样水肿的OCTA研究  

An Optical Coherence Tomography Angiography Study of Pseudophakic Cystoid Macular Edema

作　　者：李晓晓[1] 张丽娜[2] 冷林 齐莹莹 王艳萍[1] Xiaoxiao Li;Lina Zhang;Lin Leng;Yingying Qi;Yanping Wang(Qingdao University, Qingdao ShandongDepartment of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao Shandong)

机构地区：[1]青岛大学,山东青岛 [2]青岛大学附属医院,眼科,山东青岛

出　　处：《眼科学》2018年第1期66-72,共7页Hans Journal of Ophthalmology

基　　金：山东省优秀中青年科学家科研奖励基金项目(BS2013YY051)。

摘　　要：目的:使用光学相干断层扫描血管造影术(Optical Coherence Tomography Angiography, OCTA)对白内障术后黄斑囊样水肿患者的黄斑区视网膜厚度及血流情况进行研究。材料:本研究为前瞻性研究,收集2017年4月到2018年2月期间就诊于青岛大学附属医院眼科的白内障术后黄斑囊样水肿患者20例20只眼,正常白内障术后患者20例20只眼,利用OCTA测量白内障术后黄斑囊样水肿患者治疗前后、正常白内障术后患者的黄斑区视网膜厚度,黄斑的灌注、血管密度并进行分析。结果:正常组黄斑血管密度为19.23 &#177;1.88,灌注密度为0.429 &#177;0.039,黄斑区视网膜厚度为254.12 &#177;22.02 μm,白内障术后黄斑囊样水肿组黄斑血管密度为18.66 &#177;2.911,灌注密度为0.408 &#177;0.045,黄斑区视网膜厚度为482.15 &#177;19.23 μm,黄斑囊样水肿组黄斑血管、灌注密度较正常组减少(P <0.05),黄斑区视网膜厚度增加(P <0.01)。经过曲安奈德治疗后,白内障术后黄斑囊样水肿组黄斑血管密度为19.06 &#177;2.911,灌注密度为0.418 &#177;0.031,黄斑区视网膜厚度为268.34 &#177;17.14 μm,较治疗前血管密度、灌注密度增加(P <0.05),黄斑区视网膜厚度减少(P <0.01)。结论:白内障术后黄斑水肿患者黄斑区视网膜厚度增加,血流密度及灌注密度减少。经曲安奈德治疗后,白内障术后黄斑水肿患者黄斑区视网膜厚度较治疗前减少,血管密度及灌注密度较治疗前增加。Objective: To study the central foveal thickness (CFT) and macular vascular density in pseudo-phakic cystoid macular edema (PCME) patients using optical coherence tomography angiography (OCTA). Materials: This study was a prospective study. 20 eyes 20 patients with PCME and 20 eyes of 20 normal patients after cataract surgery in the affiliated hospital of Qingdao University from April 2017 to February 2018 were enrolled. The CFT, macular vascular density, macular perfusion density of normal patients after cataract surgery, patients before and after triamcinolone acetonide injection in patients with PCME were measured by OCTA, and we analyzed the material. Results: The macular vascular density in normal group was 19.23 +-1.88, the macular perfusion density was 0.429 +-0.039, the CFT was 254.12+-22.02 μm. The macular density of PCME group was 18.66 +-2.911, the perfusion density was 0.408 +-0.045, the CFT was 482.15 +-19.23 μm. The macular vascular density and the macular perfusion density of PCME group were lower than those in normal group (P < 0.05). The CFT was increased (P < 0.01). After triamcinolone acetonide treatment, the macular vascular density of PCME group was 19.06 ± 2.911, the perfusion density was0.418 ± 0.031, and the CFT was 268.34 ± 17.14 μm, which was higher than the pre-treatment vascular density and perfusion density (P < 0.05), and CFT in macular was decreased (P < 0.01). Conclusion: The macular vascular density and perfusion density were decreased in PCME patients, and the CFT was increased. After triamcinolone acetonide treatment, the CFT of PCME patients was reduced than pre-treatment, and the macular vascular density and perfusion density were increased than pre-treatment.

关 键 词：光学相干断层扫描血管造影 白内障术后黄斑囊样水肿 血流密度 黄斑中心凹厚度 

分 类 号：R5[医药卫生—内科学]