MXene QDs-Eu³⁺双发射荧光传感构建及其对强力霉素的分析应用  

Construction of MXene QDs-Eu3+ Dual-Emission Fluorescence Sensor and Its Analytical Application to Doxycycline

作　　者：汤子怡 武会芳 

机构地区：[1]南通大学化学化工学院,江苏 南通

出　　处：《物理化学进展》2024年第3期417-426,共10页Journal of Advances in Physical Chemistry

摘　　要：鉴于四环素类抗生素大量使用造成的环境污染以及人体肝损伤、肠道功能紊乱和过敏等不良反应,亟需开发一种灵敏度高、操作简便、价格低廉的四环素类抗生素残留检测方法。荧光法具有操作简单、成本低廉、可视化等优点,因此,本工作基于MXene QDs和铕离子构建了可选择性检测强力霉素(DOX)的比率荧光探针。以尿酸和单层Ti3CN为原料通过水热法制备得MXene QDs,MXene QDs与Eu3+通过自组装构建得到MXene QDs-Eu3+双发射荧光探针,用于DOX的选择性检测。并通过优化探针体系中的MXene QDs浓度、Eu3+浓度、pH和响应时间等实验条件,探究该双发射荧光探针对强力霉素的定量和选择性检测性能。结果表明,该荧光探针对DOX具有特异性识别能力,且荧光强度比(F615/F421)与不同浓度DOX (0∼30 μM)之间存在良好的线性关系,表明其在TCs残留检测中具有良好应用前景。Given the environmental pollution, liver damage, intestinal dysfunction, and allergic reactions caused by the extensive use of tetracycline antibiotics, there is an urgent need to develop a sensitive, simple, and cost-effective method for detecting residual tetracycline antibiotics. The fluorescence method possesses advantages such as simple operation, low cost, and visualizability. Therefore, this work constructs a ratio fluorescence probe for the selective detection of doxycycline based on MXene QDs and rare earth ions. We prepared MXene QDs using uric acid and single-layer Ti3CN as raw materials through a hydrothermal method. The MXene QDs-Eu3+ dual-emission fluorescent probe was constructed by self-assembly of MXene QDs and Eu3+, which was used for the selective detection of streptomycin. By optimizing the experimental conditions such as the concentration of MXene QDs, Eu3+, pH, and response time in the probe system, this dual-emission fluorescent probe was explored for quantitative and selective detection of streptomycin. Findings show that the fluoresce

关 键 词：荧光探针 MXene QDs 强力霉素 镧系元素 

分 类 号：R28[医药卫生—中药学]