NLR、GPR及25-(OH)水平与阻塞性睡眠呼吸暂停低通气综合征患者颈动脉内膜中层厚度关系的研究进展  

Research Progress on the Relationship between NLR, GPR, 25-(OH) Levels and Carotid Intima-Media Thickness in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：薛科 韩吉祥[2] 

机构地区：[1]青海大学研究生院临床医学院,青海 西宁 [2]青海大学附属医院老年医学科,青海 西宁

出　　处：《临床个性化医学》2024年第1期24-31,共8页Journal of Clinical Personalized Medicine

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见的睡眠障碍,其发病机制复杂,涉及多种因素。近年来,阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的发病率逐年上升,成为了严重威胁人类健康的疾病之一。研究表明,颈动脉内膜中层厚度(IMT)是评估OSAHS患者心血管疾病风险的重要指标。近年来,许多学者对IMT及其与OSAHS相关的生物标志物如NLR、GPR及25-(OH)水平进行了深入研究。本文将综述这些研究进展,进一步阐述中性粒细胞计数与淋巴细胞计数比(NLR)、γ-谷氨酰转肽酶(GGT)与血小板比值(GPR)和25-(OH)水平与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者颈动脉内膜中层厚度(IMT)之间的关系,旨在为OSAHS的诊断、治疗和预防提供参考。同时,本文也将探讨未来在该领域的研究方向和趋势。Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder with a complex pathogenesis involving multiple factors. In recent years, the incidence of OSAHS has been increasing annually, becoming one of the serious diseases that threaten human health. Studies have shown that carotid intima-media thickness (IMT) is an important indicator for evaluating the risk of car-diovascular disease in OSAHS patients. In recent years, many scholars have conducted in-depth re-search on IMT and its related biomarkers such as NLR, GPR, and 25-(OH) levels in OSAHS. This arti-cle will review the research progress in these areas, further elucidating the relationship between neutrophil-to-lymphocyte ratio (NLR), gamma-glutamyl transpeptidase (GGT)-to-platelet ratio (GPR), 25-(OH) levels and carotid intima-media thickness (IMT) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS), aiming to provide references for the diagnosis, treatment, and prevention of OSAHS. At the same time, this article will also explore future research directions and trends in this field.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 中性粒细胞计数与淋巴细胞计数比 γ-谷氨酰转肽酶(GGT)与血小板比值 25-(OH) 颈动脉内膜中层厚度 

分 类 号：R76[医药卫生—耳鼻咽喉科]