重症COVID-19患者凝血功能异常所致血栓形成的研究进展  

Research Progress on Thrombosis Caused by Coagulation Disorders in Severe COVID-19 Patients

作　　者：王文静 王卓亚[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院老年医学科,青海 西宁

出　　处：《临床个性化医学》2024年第2期447-457,共11页Journal of Clinical Personalized Medicine

摘　　要：2019年12月左右,新型冠状病毒肺炎出现,这场新冠肺炎疫情传染性极强、传播速度极快,成为全球重大公共卫生事件,危及着全人类的健康。世界各国卫生组织竭尽全力抗击着这场疫情战役,虽然通过提高病例检测能力、社会防御意识和促进疫苗注射等因素可能在很大程度上对疫情进行了有效防控,但全球多个国家依旧已经或正在经历着多次暴发。绝大部分患者是可以痊愈的,但仍有部分患者转化为重症或危重症,严重者甚至死亡。对于重症新型冠状病毒肺炎患者,除了呼吸衰竭外,凝血功能异常引起的相关临床并发症也是使患者病情突然恶化,甚至死亡的重要原因之一。根据ISTH发布的弥散性血管内凝血病(DIC)标准,一些重度COVID-19感染患者可发生凝血功能障碍,并伴有爆发性凝血激活,导致广泛的微血管血栓形成和凝血因子消耗。已有研究结果显示,凝血功能异常与COVID-19患者的病重率和死亡率密切相关。本文通过对COVID-19患者中凝血功能异常和其发生的相关机制、治疗策略等方面进行综述,以便为COVID-19及之后可能出现的类似疾病的治疗提供参考方案。In December 2019, a new type of Coronavirus pneumonia emerged, the epidemic is highly infectious, spread very fast, the crowd has a universal susceptibility to become a major global public health event, endangering the health of all mankind. Health organizations around the world are doing their best to fight the epidemic, although by improving case-detection capabilities, factors such as social defense awareness and self-protection ability, promotion of vaccination and herd immunity may have effectively prevented and controlled the epidemic to a large extent, but many countries around the world have still experienced or are experiencing multiple outbreaks. The vast majority of patients can be cured, but there are still some patients may be transformed into severe or critical illness, serious or even death. For severe Coronavirus pneumonia, in addition to respiratory failure, coagulation disorders caused by clinical complications is also a sudden deterioration of the disease, even one of the important causes of death. According to the disseminated intravascular coagulation (DIC) criteria issued by ISTH, some patients with severe COVID-19 infection can develop coagulation dysfunction with explosive coagulation activation, resulting in extensive microvascular thrombosis and coagulation factor depletion. Previous studies have shown that the coagulation disorders is closely related to the serious illness rate and death rate of patients with COVID-19. In this review, the mechanism and treatment strategies of coagulation disorders in COVID-19 patients were reviewed in order to provide reference for the treatment of COVID-19 and similar diseases.

关 键 词：新型冠状病毒 重型 凝血功能异常 血栓形成 治疗 

分 类 号：R47[医药卫生—护理学]