氨甲环酸在踝关节骨折围术期中的有效性分析  

Analysis of the Effectiveness of Tranexamic Acid in the Perioperative Period of Ankle Fracture

作　　者：艾孜木江·阿卜杜合力力 阿布都哈力克·阿布都日衣木 

机构地区：[1]新疆维吾尔自治区新收犯监狱医院创伤骨科,新疆 乌鲁木齐 [2]喀什地区第二人民医院创伤骨科,新疆 喀什

出　　处：《临床个性化医学》2024年第3期869-877,共9页Journal of Clinical Personalized Medicine

摘　　要：目的:探讨氨甲环酸在踝关节骨折围术期的临床有效性。方法:根据纳入标准,回顾性筛选2021年4月至2023年03月于喀什地区第二人民医院骨科行踝关节骨折切开复位钢板内固定术的178例患者,根据围术期是否应用氨甲环酸分成对照组和治疗组,对照组(n = 74)予以治疗踝关节骨折切开复位钢板内固定术,治疗组(n = 104)在对照组治疗基础上加用氨甲环酸治疗,观察2组术前与术后第1天和第5天血常规指标(红细胞、血红蛋白、红细胞压积、血小板、红细胞平均体积和平均血红蛋白浓度),比较两组血清总蛋白、白蛋白和血清铁离子的变化。结果:① 术前资料:术前两组患者的年龄、性别构成、体质量指数、高血压、糖尿病、骨质疏松症、手术时间以及血红蛋白、血小板、红细胞平均体积、平均血红蛋白浓度、血清总蛋白和白蛋白指标进行比较,差异均无显著性意义(P > 0.05);② 两组患者术后第1,5天血小板和红细胞平均体积比,差异均无显著性意义(P > 0.05);术后第1,5天血红蛋白比,差异有显著性意义(P Objective: To investigate the clinical effectiveness of tranexamic acid in perioperative ankle fracture. Methods: According to the inclusion criteria, retrospective screening of 178 patients undergoing open reduction plate internal fixation of ankle fracture in the orthopedic department of the second people’s hospital of Kashgar Region from April 2021 to March 2023, according to the application of tranexamic acid during the perioperative period, the control group (n = 74) was treated with open reduction plate fixation, the treatment group (n = 104) added tranexamic acid to the control group, observe the 2 blood routine indexes (red blood cells, hemoglobin, hematocrit, platelet, red blood cell volume and mean hemoglobin concentration before and postoperative days 1 and 5), changes in serum total protein, albumin and serum iron ions were compared between the two groups. Res

关 键 词：氨甲环酸 踝关节骨折 止血 贫血 踝关节骨折切开复位钢板内固定术 

分 类 号：R68[医药卫生—骨科学]