健脾平肝化浊方干预高血压早期肾损害的临床研究  

Clinical Study on the Intervention of Jianpi Pinggan Huazhuo Prescription on Early Renal Damage of Hypertension

作　　者：董振华 徐舒雨 尤清文 张书研 程芳 

机构地区：[1]浦东新区金杨社区卫生服务中心中医科,上海

出　　处：《临床个性化医学》2024年第4期1357-1363,共7页Journal of Clinical Personalized Medicine

基　　金：上海市浦东新区健康委员会浦东名中医项目(NO: PWRzm2020-10);浦东新区“国家中医药发展综合改革试验区”建设–中医高级师承人才培养。

摘　　要：目的:观察健脾平肝化浊方治疗高血压早期肾损伤的临床疗效。方法:纳入上海市浦东新区金杨社区卫生服务中心中医科门诊及病房的高血压伴早期肾损伤的患者90例,随机分为中药干预组和对照组,对照组给予西医常规治疗,中药干预组在对照组基础上给予健脾平肝化浊方进行干预。疗程为3个月,观察两组治疗前后血压变化,早期肾损伤指标胱抑素C、β2-MG、NAG、尿mALB变化情况。结果:治疗3个月后,中药干预组收缩压(134.12 ± 4.62) mmHg低于对照组(137.10 ± 3.64) mmHg (t = −3.232, P = 0.002);舒张压(78.43 ± 4.59) mmHg也较对照组(81.86 ± 5.96) mmHg降低(t = 2.908, P = 0.005);两组降压疗效比较,中药干预组总有效率为80.95%明显高于对照组的55.0% (χ2 = 6.647, P = 0.036)两组β2-MG水平较治疗前下降,但无明显统计学差异。中药干预组尿mALB水平(69.56 ± 6.45) mg/L较对照组(73.42 ± 7.34) mg/L显著下降(t = −2.295, P = 0.024)。结论:健脾平肝化浊方可协同降低血压,改善高血压早期肾损害指标,一定程度上可逆转靶器官损害。Objective: This paper aims to observe the clinical effect of Jianpi Pinggan Huazhuo prescription on early renal injury of hypertension. Methods: 90 patients with hypertension and early renal injury were enrolled in the outpatient department and ward of Jinyang Community Health Service Center of Pudong New Area, Shanghai. These people were divided into two groups—Chinese herbs intervention group and control group by random number table method. The control group was given conventional Western medicine treatment, and the Chinese herbs intervention was given oral Jianpi Pinggan Huazhuo prescription on the basis of the control group. The treatment course was 3 months. The changes of blood pressure, cystatin C, β2-MG, NAG and urinary mALB of the two groups were compared. Results: After 3 months of treatment, the systolic blood pressure (134.12 ± 4.62) mmHg in the intervention group was low

关 键 词：高血压 早期肾损伤 健脾平肝化浊方 

分 类 号：R54[医药卫生—心血管疾病]