丹参酮IIA治疗大骨节病的潜在机制探讨  

Exploration of the Potential Mechanisms of Tanshinone IIA in the Treatment of Kashin-Beck Disease

作　　者：邢颖 丁晓清 阮涛 赵云舟 徐柯 张杰[2] 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第二医院骨伤二科,黑龙江 哈尔滨

出　　处：《临床个性化医学》2024年第4期1504-1509,共6页Journal of Clinical Personalized Medicine

基　　金：黑龙江省中医药管理局国医大师学术思想传承科研课题(ZHY2023-154)。

摘　　要：大骨节病(Kashin-Beck disease, KBD)是一种以关节软骨病变为主的地方性疾病。属中医“痹症”范畴,其发生发展与瘀血密切相关。中药以其价格低廉、疗效安全,属于天然性植物药,越来越受到研究者的关注,丹参酮IIA (Tanshinone IIA, Tan IIA)是中药丹参的主要有效成分,具有抗炎、保护软骨细胞外基质(ECM)、抗血小板聚集、抗血栓形成等作用,对多种痹症有效,目前尚未有丹参酮IIA应用于大骨节病的研究,本文探讨了丹参酮IIA可能应用于大骨节病的潜在机制,以期为大骨节病的治疗提供新的思路。Kashin-Beck disease (KBD) is a regional disease primarily characterized by articular cartilage lesions. It falls under the category of “bi syndrome” in traditional Chinese medicine, and its development is closely related to blood stasis. Chinese herbal medicine, known for its low cost and safe efficacy, is increasingly gaining the attention of researchers as a natural plant-based remedy. Tanshinone IIA (Tan IIA), the main active ingredient in the Chinese herb Danshen, possesses anti-inflammatory properties, protects the extracellular matrix (ECM) of chondrocytes, prevents platelet aggregation, and inhibits thrombus formation, among other effects. It has been effective against various types of bi syndrome. To date, there has been no research on the application of Tanshinone IIA in the treatment of Kashin-Beck disease. This article explores the potential mechanisms by which Tanshinone IIA could be applied to Kashin-Beck disease, with the aim of providing new perspectives for its treatment.

关 键 词：大骨节病 丹参酮IIA 痹症 探讨 

分 类 号：R68[医药卫生—骨科学]