苓桂术甘汤治疗射血分数降低型心力衰竭的临床应用及作用机制的研究进展  

Research Progress on the Clinical Application and Mechanism of Action of Linggui Zhugan Decoction in Treating Heart Failure with Reduced Ejection Fraction

作　　者：党晨玮 陈会君[2] 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第二医院心血管二科,黑龙江 哈尔滨

出　　处：《临床个性化医学》2024年第4期1888-1895,共8页Journal of Clinical Personalized Medicine

摘　　要：本文旨在探讨苓桂术甘汤对射血分数降低型心力衰竭(HFrEF)的治疗效果及其作用机制。心力衰竭是一种严重的临床综合征,HFrEF作为其中一种形式,对患者生活质量和生存率构成重大影响。尽管西药治疗已取得一定进展,但存在局限性,因此,结合中医辨证治疗的苓桂术甘汤显示出了潜在的治疗优势。本综述回顾了苓桂术甘汤的组方分析、临床应用、以及治疗HFrEF的多方面作用机制,包括改善心肌能量代谢、调节脂质代谢、抑制氧化应激反应和心肌纤维化等。研究表明,苓桂术甘汤能够显著改善HFrEF患者的临床症状和心功能,且安全性良好。然而,研究的局限性和未来研究方向也被讨论,以期为中西医结合治疗HFrEF提供新的思路和方向。This paper aims to explore the therapeutic effects of Linggui Zhugan Decoction on heart failure with reduced ejection fraction (HFrEF) and its mechanisms of action. Heart failure is a serious clinical syndrome, and HFrEF, as one of its forms, significantly impacts patients’ quality of life and survival rate. Although Western medicine has made certain progress, it has limitations. Therefore, Linggui Zhugan Decoction, combined with traditional Chinese medicine syndrome differentiation and treatment, has shown potential therapeutic advantages. This review summarizes the formula analysis of Linggui Zhugan Decoction, its clinical application, and its multifaceted mechanisms of action in treating HFrEF, including improving myocardial energy metabolism, regulating lipid metabolism, inhibiting oxidative stress reactions, and myocardial fibrosis. Studies have shown that Linggui Zhugan Decoction can significantly improve the clinical symptoms and cardiac function of HFrEF patients, with good safety. However, the limitations of the research and future research directions are also discussed, in the hope of providing new ideas and directions for the integrated treatment of HFrEF with Chinese and Western medicine.

关 键 词：苓桂术甘汤 心力衰竭 心肌能量代谢 脂质代谢 氧化应激 心肌纤维化 

分 类 号：R54[医药卫生—心血管疾病]