组蛋白去乙酰化酶3:腹主动脉瘤治疗新靶点?  

Histone Deacetylase 3: A New Target for the Treatment of Abdominal Aortic Aneurysm?

作　　者：刘伟炀 刘仁贵 吴国栋 

机构地区：[1]大理大学第一附属医院血管外科,云南 大理

出　　处：《临床个性化医学》2024年第4期2065-2071,共7页Journal of Clinical Personalized Medicine

基　　金：云南省教育厅科学研究基金项目(2024Y907)。

摘　　要：组蛋白去乙酰化酶是一组能调节组蛋白和非组蛋白赖氨酸残基去乙酰化的酶类,在染色体的结构修饰和基因表达调控发挥着重要的作用。近年来随着对组蛋白去乙酰化酶3研究不断深入,发现其与腹主动脉瘤有着密切关系。腹主动脉瘤是多种原因导致动脉中层结构破坏的动脉扩张性疾病,主要发病机制为细胞外基质破坏性重构、血管平滑肌细胞凋亡、炎症与氧化应激等。而组蛋白去乙酰化酶3可能通过上述途径参与腹主动脉瘤的发生发展。因此,本文通过对组蛋白去乙酰化酶3和腹主动脉瘤的致病机制进行综述,为腹主动脉瘤的治疗提供新思路和新靶点。Histone deacetylases are a group of enzymes that can regulate the deacetylation of histone and non-histone lysine residues, and play an important role in chromosome structural modification and gene expression regulation. In recent years, with the deepening of research on histone deacetylase 3, it has been found that it is closely related to abdominal aortic aneurysm. Abdominal aortic aneurysm is a kind of arterial dilatation disease that causes the destruction of the middle layer of the artery. The main pathogenesis is the destructive remodeling of the extracellular matrix, the apoptosis of vascular smooth muscle cells, inflammation and oxidative stress. Histone deacetylase 3 may be involved in the development of abdominal aortic aneurysm through the above pathways. Therefore, this article provides a new idea and a new target for the treatment of abdominal aortic aneurysm by summarizing the pathogenic mechanism of histone deacetylase 3 and abdominal aortic aneurysm.

关 键 词：组蛋白去乙酰化酶3 腹主动脉瘤 血管平滑肌细胞 炎症 研究进展 

分 类 号：R54[医药卫生—心血管疾病]