水飞蓟素防治代谢综合征的作用机制研究进展  

Research Progress on the Mechanism of Silymarin in Preventing and Treating Metabolic Syndrome

作　　者：张皓然 李娟[1] 杜丽坤[1] 

机构地区：[1]黑龙江中医药大学附属第一医院内分泌二科,黑龙江 哈尔滨

出　　处：《临床个性化医学》2024年第4期2077-2083,共7页Journal of Clinical Personalized Medicine

基　　金：基于本草考证和栽培工艺探究水飞蓟的综合利用价值,编号:ZYW2023-026。

摘　　要：目的:水飞蓟种子中含有大量的黄酮类化合物,主要为水飞蓟素。本文对水飞蓟素防治代谢综合征的作用机制以及研究进展进行综述。为研发以防治代谢综合征为主要作用的药品或保健药食提供科学依据。方法:查阅有关水飞蓟素防治代谢综合征的相关文献,并系统总结与梳理。结果:水飞蓟素具有调节血脂、降低血糖、抗炎、抗肿瘤、抗氧化、抗凝血、抗动脉粥样硬化等药理作用,可以改善氧化应激、改善胰岛素抵抗(IR)、肥胖、保护血管内皮、改善肠道菌群、抑制血小板聚集、抑制炎症因子表达。结论:水飞蓟素作为无肝脏不良反应的保肝降脂药,具有抗氧化、抗炎、防治代谢综合征等功能,有望成为新型有效的保健食品。Objective: The seeds of silymarin contain a large amount of flavonoids, mainly silymarin. This article reviews the mechanism of action and research progress of silymarin in the prevention and treatment of metabolic syndrome to provide a scientific basis for the development of drugs or health supplements with the main function of preventing and treating metabolic syndrome. Method: We review relevant literature on the prevention and treatment of metabolic syndrome with silymarin, and systematically summarize and sort it out. Results: Silymarin has the pharmacological effects of regulating blood lipids, lowering blood sugar, anti-inflammatory, anti-tumor, antioxidant, anticoagulant, anti atherosclerosis, etc. It can improve oxidative stress, improve insulin resistance (IR), obesity, regulate lipid metabolism, protect vascular endothelium, improve intestinal flora, inhibit platelet aggregation, and inhibit the expression of inflammatory factors. Conclusion: Silymarin, as a liver protective and lipid-lowering drug without adverse liver reactions, has functions such as antioxidant, anti-inflammatory, and prevention and treatment of metabolic syndrome, and is expected to become a new and effective health food.

关 键 词：水飞蓟素 代谢综合征 药理靶点 作用机制 

分 类 号：R28[医药卫生—中药学]