绞股蓝皂苷抗肿瘤活性成分及机制研究进展  

Research Progress on Anti-Tumor Active Components and Mechanisms of Gypenosides

作　　者：刘梅玉 黄俊伟 廖海东 应勇 曾祥泰 

机构地区：[1]赣南医科大学第一附属医院甲状腺疝外科,江西 赣州 [2]赣州市甲状腺肿瘤重点实验室,江西 赣州 [3]龙南市第一人民医院普外科,江西 赣州

出　　处：《临床个性化医学》2024年第4期2262-2269,共8页Journal of Clinical Personalized Medicine

基　　金：2023年度江西省中医药科技计划项目(编号:2023B0202);赣州市甲状腺肿瘤重点实验室(编号:20220101-24)。

摘　　要：绞股蓝皂苷作为绞股蓝中的一种重要天然活性成分,近年来受到广泛关注。研究表明,绞股蓝皂苷具有多种生物活性,包括抗氧化、抗炎、降糖、降脂、心血管保护及免疫调节等作用,其中抗肿瘤活性尤为突出,可能与其调节细胞增殖、诱导凋亡、抑制肿瘤细胞转移等机制密切相关。对绞股蓝皂苷的抗肿瘤活性成分及作用机制进行了系统归纳和分析,旨在为绞股蓝皂苷在抗癌药理作用领域的进一步研究提供参考。Gypenosides, as an important natural active ingredient found in Gynostemma pentaphyllum, has received widespread attention in recent years. Studies have shown that gypenosides exhibit various biological activities, including anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, cardiovascular protection and immunomodulatory effects, among which the antitumour activity is particularly prominent, which may be closely related to its mechanisms of regulating cell proliferation, inducing apoptosis and inhibiting tumour cell metastasis. This article systematically summarizes and analyzes the anti-tumor bioactive components and mechanisms of gypenosides, aiming to provide reference and support for further research on their pharmacological effects in cancer treatment.

关 键 词：绞股蓝皂苷 肿瘤 上皮–间充质转化 凋亡 细胞周期 

分 类 号：R28[医药卫生—中药学]